Evidence map›Paper›PMID 41523267›Full record

Articlenpj drug discovery2026

Development of potent, selective cPLA

Anastasiia V Sadybekov, Marlon Vincent Duro, Shaowei Wang, Brandon Ebright, Dante Dikeman, Cristelle Hugo, Bilal Ersen Kerman, Qiu-Lan Ma, Antonina L Nazarova, Arman A Sadybekov and 4 more

Abstract read
In one paragraph

Article in npj drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A perspective: PLA2G4A as drug target for vascular inflammation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Anastasiia V Sadybekov *Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA USA.
Marlon Vincent Duro *Department of Radiology, Keck School of Medicine, Los Angeles, CA USA.
Shaowei Wang *Department of Neurology, Keck School of Medicine, Los Angeles, CA USA.
Brandon EbrightDepartment of Clinical Pharmacy, Mann School of Pharmacy, Los Angeles, CA USA.
Dante DikemanDepartment of Clinical Pharmacy, Mann School of Pharmacy, Los Angeles, CA USA.
Cristelle HugoDepartment of Neurology, Keck School of Medicine, Los Angeles, CA USA.
Bilal Ersen KermanDepartment of Neurology, Keck School of Medicine, Los Angeles, CA USA.
Qiu-Lan MaDepartment of Neurology, Keck School of Medicine, Los Angeles, CA USA.
Antonina L NazarovaDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA USA.
Arman A SadybekovDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA USA.
Isaac AsanteDepartment of Ophthalmology, Keck School of Medicine, Angeles, CA USA.
Stan G LouieDepartment of Clinical Pharmacy, Mann School of Pharmacy, Los Angeles, CA USA.
Vsevolod KatritchDepartment of Quantitative and Computational Biology, University of Southern California, Los Angeles, CA USA.
Hussein N YassineDepartment of Neurology, Keck School of Medicine, Los Angeles, CA USA.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI · 2020 to 2026
$27.8M
The delivery of essential fatty acids to the Brain in Alzheimer's diseaseR01AG054434 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$5.4M
Biomarkers of ABCA1 mediated functions in Alzheimers diseaseR01AG055770 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2017 to 2021
$4.2M
ApoE, ABCA1 and endosomal dysregulation in ADR01AG067063 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2020 to 2024
$3.4M
Drug Development for Alzheimer's neuroinflammationU01AG094622 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Kai Chen, VSEVOLOD KATRITCH · 2025 to 2026
$3.2M
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4 Diversity SupplementRF1AG076124 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARVANITAKIS, ZOE, YASSINE, HUSSEIN N · 2022 to 2024
$2.5M
Brain cPLA2 as a mechanism for neuroinflammation in AD/ADRD with and without APOE4R01AG076124 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Zoe Arvanitakis, Hussein N Yassine · 2025 to 2026
$1.6M
Efficient synthon-based modular screening of Giga-to-Terra-scale virtual librariesR01GM147537 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KATRITCH, VSEVOLOD · 2022 to 2024
$1.2M
Computational approaches to discover ligands with new chemotypes and functional propertiesR35GM153437 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VSEVOLOD KATRITCH · 2024 to 2026
$899k
DHA brain delivery by APOE genotypeR21AG056518 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YASSINE, HUSSEIN N · 2018 to 2019
$464k
NCATS NIH HHS UL1 TR000004NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG054434NIA NIH HHS R01 AG055770NIA NIH HHS R01 AG067063NIA NIH HHS R01 AG076124NIA NIH HHS R21 AG056518NIA NIH HHS RF1 AG076124NIA NIH HHS U01 AG094622NIGMS NIH HHS R01 GM147537NIGMS NIH HHS R35 GM153437
6 · The paper itself

Abstract

Chronic neuroinflammation plays a key role in the progression of Alzheimer's disease (AD), and the cytosolic calcium-dependent phospholipase A

Indexed as

Drug discoveryVirtual screening

Identifiers

PMID41523267
PMCPMC12779542

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.