Evidence map›Paper›PMID 41523255›Full record

ArticleAmerican journal of cancer research2025

IDH1 and ATRX mutations synergistically modulate cell proliferation and ferroptosis in glioblastoma cells.

Siqi Liu, Xiangnan Xiao, Ang Li, Chao Ren, Bin Meng, Xiyu Huang, Xiao Wang, Lu Zhang, Mafei Xu

Abstract read
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siqi LiuDepartment of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University Hefei, Anhui, China.
Xiangnan XiaoDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Ang LiDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Chao RenDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Bin MengDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Xiyu HuangDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Xiao WangDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Lu ZhangDepartment of Cell Biology, School of Life Sciences, Anhui Medical University Hefei, Anhui, China.
Mafei XuDepartment of Pathophysiology, School of Basic Medical Sciences, Anhui Medical University Hefei, Anhui, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IDH1 and ATRX mutations frequently co-occur in several glioma subtypes, including secondary glioblastomas (GBMs), suggesting that these alterations may function cooperatively during tumor development. However, the molecular basis of their interaction remains poorly defined. In present study, we demonstrate that the

Indexed as

ATRXferroptosisgliomaIDH1

Identifiers

PMID41523255
PMCPMC12789910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.