Evidence map›Paper›PMID 41523237›Full record

ArticleAmerican journal of cancer research2025

Macrophage-derived exosomes induce M2 microglial polarization to alleviate bone cancer pain.

Jiaxin Xie, Libiao Yuan, Jiyan Li, Yaping Liu, Xiangming Li, Zhiqiang Dai, Weixing Ding, Zhangxiang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jiaxin XieDepartment of Pain, First Affiliated Hospital of Kunming Medical University Kunming 650000, Yunnan, China.
Libiao YuanDepartment of Pain, First Affiliated Hospital of Kunming Medical University Kunming 650000, Yunnan, China.
Jiyan LiDepartment of Pain, First Affiliated Hospital of Kunming Medical University Kunming 650000, Yunnan, China.
Yaping LiuDepartment of Eye, Kunming Tongren Hospital Kunming 650000, Yunnan, China.
Xiangming LiDepartment of Pain, First Affiliated Hospital of Kunming Medical University Kunming 650000, Yunnan, China.
Zhiqiang DaiDepartment of Neurosurgery, The 920th Hospital of Joint Logistics Support Force of The Chinese People's Liberation Army Kunming 650000, Yunnan, China.
Weixing DingDepartment of Pain, Qujing Second People's Hospital Qujing 655009, Yunnan, China.
Zhangxiang HuangDepartment of Pain, First Affiliated Hospital of Kunming Medical University Kunming 650000, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone cancer pain (BCP) is a frequent and debilitating complication in patients with malignant tumors, arising from a multifactorial interplay of bone destruction, neural injury, and inflammatory responses. Microglia can polarize into either an M1 phenotype, which aggravates nociception, or an M2 phenotype, which facilitates pain resolution. Activation of the TLR4/NF-κB signaling cascade is known to drive M1 polarization, thereby amplifying inflammation and neuronal damage. This study aimed to investigate whether macrophage-derived exosomes could mitigate BCP by modulating the TLR4/NF-κB pathway, suppressing M1 polarization, and enhancing M2 microglial polarization.

Indexed as

bone cancer paininflammation regulationMacrophage-derived exosomesmicroglial polarizationTLR4/NF-κB signaling pathway

Identifiers

PMID41523237
PMCPMC12789913

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.