ArticleIJU case reports2026
Neoadjuvant Avelumab Plus Axitinib Enabling Curative Resection of Renal Cell Carcinoma With Direct Liver Invasion: A Case Report.
Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Direct liver invasion by renal cell carcinoma (RCC) is rare and often precludes margin-negative resection. Herein, we report a case where neoadjuvant treatment with avelumab plus axitinib downstaged the disease, enabling complete surgical resection. Case Presentation: A 67-year-old woman presented with gross hematuria. Computed tomography revealed a 70-mm right renal mass with direct liver invasion. Core biopsy confirmed clear-cell RCC and clinical stage cT4N0M0. She received ten cycles of avelumab (10 mg/kg, biweekly) plus axitinib (10 mg/day), resulting in tumor shrinkage to 35 mm. She underwent open radical nephrectomy with partial hepatectomy, achieving negative surgical margins. Histological examination revealed hepatic parenchymal invasion, with no viable tumor at the inked hepatic margin. Adjuvant therapy was not administered. The patient has remained disease-free for 24 months. Conclusion: In select cases of organ-invasive non-metastatic RCC, short-term neoadjuvant therapy with avelumab plus axitinib may allow for complete resection and prolonged disease control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.