Evidence map›Paper›PMID 41523185›Full record

ArticleBrain communications2026

Cortical asymmetry in autosomal dominant Alzheimer's disease progression.

Agnès Pérez-Millan, Neus Falgàs, Beatriz Bosch, Sergi Borrego-Écija, Anna Antonell, Guadalupe Fernández-Villullas, Diana Esteller-Gauxax, Adrià Tort-Merino, Núria Bargalló, Mircea Balasa and 19 more

Abstract read
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Agnès Pérez-MillanAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.ORCID https://orcid.org/0000-0002-3006-9792
Neus FalgàsAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Beatriz BoschAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Sergi Borrego-ÉcijaAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Anna AntonellAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Guadalupe Fernández-VillullasAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Diana Esteller-GauxaxAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Adrià Tort-MerinoAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Núria BargallóImage Diagnostic Centre, Hospital Clínic de Barcelona, Barcelona 08036, Spain.
Mircea BalasaAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
Albert LladóAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.
David AguillonGrupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín 050010, Colombia.
Patricio ChremInstitute of Neurological Research, FLENI, Buenos Aires C1428AQK, Argentina.
Gregory S DayDepartment of Neurology, Mayo Clinic in Florida, Jacksonville, FL 32224, USA.
Emma DevenneyNeuroscience Research Australia, Sydney 2031, Australia.
Edward D HueyDepartment of Psychiatry and Human Behavior, Alpert Medical School, Brown University, Providence 02912, USA.
Takeshi IkeuchiNiigata University, Niigata 8050, Japan.ORCID https://orcid.org/0000-0001-8828-8085
Mathias JuckerGerman Center for Neurodegenerative Diseases (DZNE), Tübingen 72076, Germany.
Kensaku KasugaBrain Research Institute, Niigata University, Niigata 8050, Japan.
Jonathan VögleinDepartment of Neurology, LMU University Hospital, LMU Munich, Munich 81377, Germany.ORCID https://orcid.org/0000-0002-5965-838X
Jee Hoon RohDepartments of Physiology and Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Korea.ORCID https://orcid.org/0000-0002-3243-0529
Paolo VitaliTranslational Neuroimaging Laboratory, Department of Neurology and Neurosurgery, Psychiatry and Pharmacology and Therapeutics, McGill University Research Centre for Studies in Aging, Montreal Neurological Institute-Hospital, Douglas Research Institute, McGill University, Montreal, Canada H3A 2B4.ORCID https://orcid.org/0000-0001-8953-1542
Ana Luisa Sosa OrtizDementias Laboratory, National Institute of Neurology and Neurosurgery, Mexico City, DF 14269, Mexico.
Jorge J Llibre-GuerraDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Brian A GordonDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0003-2109-2955
Eric McDadeDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Randall J BatemanDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-7729-1702
Raquel Sánchez-ValleAlzheimer's Disease and Other Cognitive Disorders Group, Service of Neurology, Hospital Clínic de Barcelona. Fundació Recerca Clínic Barcelona-IDIBAPS, Barcelona 08036, Spain.ORCID https://orcid.org/0000-0001-7750-896X
Dominantly Inherited Alzheimer Network (DIAN)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cortical asymmetry index evaluates the cortical thickness asymmetry between hemispheres. We investigated cortical asymmetry index in asymptomatic and symptomatic mutation carriers of autosomal dominant Alzheimer's disease to explore the brain asymmetry within the Alzheimer's disease continuum. Sixty baseline T1-weighted MRI scans were obtained from the Clinic Barcelona cohort. Baseline and longitudinal MRI data from 564 participants within the dominantly inherited Alzheimer network observational study were used as an independent, confirmatory cohort. Cerebrospinal fluid and plasma neurofilament light chain levels were included when available. Cortical thickness was calculated using Freesurfer and cortical asymmetry index was calculated via an open-source pipeline. Cross-sectional analyses examined cortical asymmetry index differences based on clinical classification and

Indexed as

Alzheimer’s diseaseAPOEautosomal dominant Alzheimer’s diseasebrainmagnetic resonance imaging

Identifiers

PMID41523185
PMCPMC12781868

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.