ArticleJournal of current glaucoma practice
Sponge Application of Mitomycin C vs Sub-Tenon Injection in Trabeculectomy: A Randomized Controlled Trial.
Article in Journal of current glaucoma practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06925412 (Sponge Application of MMC Versus Suntenon Injection in Trabeculectomy), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sponge Application of MMC Versus Suntenon Injection in Trabeculectomy
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims and background: Glaucoma represents a major driver of irreversible blindness globally, with intraocular pressure (IOP) reduction serving as the primary therapeutic objective. Trabeculectomy (TE), often augmented with mitomycin C (MMC), is considered the gold standard surgical treatment; however, its success is frequently compromised by postoperative fibrosis. Various MMC delivery techniques-such as sponge application and sub-Tenon injection (STI)-differ in their drug distribution profiles and may consequently affect surgical outcomes. Accordingly, we aimed to evaluate and compare the efficacy and safety of TE performed with sponge-applied MMC against STI-MMC. Materials and methods: This prospective, randomized, controlled clinical trial enrolled 50 patients having primary or secondary glaucoma who were randomly allocated to undergo TE with either MMC sponge application (group A, Results: Both groups achieved significant IOP reductions without intergroup differences at all postoperative intervals ( Conclusion: Both STI-MMC and sponge-applied MMC are equally effective for IOP control, though STI may produce more diffuse blebs, potentially reducing long-term complications. Further long-term studies are warranted. Clinical significance: This study demonstrates STI-MMC noninferiority compared to sponge-applied MMC in achieving sustained IOP reduction after TE while highlighting distinct bleb morphologies with potential safety implications. These findings advocate for individualized MMC selection based on patient-specific risk factors, balancing technical simplicity with potential long-term safety. Clinical trial registration: Retrospectively registered at ClinicalTrials.gov (Identifier: NCT06925412). How to cite this article: Abdelhafeez SM, Mohammed Mohammed HE, Tharwat E,
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