ReviewJournal of current glaucoma practice
Risk Factors and Genetic Markers Associated with the Development and Progression of Glaucoma: A Review.
Review in Journal of current glaucoma practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Aims: This study aims to systematically evaluate and synthesize current evidence on the environmental risk factors and genetic markers associated with the development and progression of glaucoma, with a focus on primary open-angle (POAG), normal-tension glaucoma (NTG) and angle-closure glaucoma (ACG), in order to clarify their interplay, clinical implications, and potential avenues for personalized risk assessment and therapeutic intervention. Background: Being one of the major causes of irreversible blindness in the world, glaucoma is a multifactorial optic neuropathy that has a complex interaction between clinical, environmental, and genetic factors. In this literature review, existing evidence on the risk factors and the genetic markers of glaucoma, induced by primary open-angle glaucoma (POAG), NTG, and primary angle-closure glaucoma (PACG), are synthesized. Methodology: PubMed, Scopus, Web of Science, DOAJ, and Google Scholar have been searched by using key terms ('Glaucoma,' 'POAG,' 'ACG,' 'Risk Factors,' 'Genetic Markers,' etc.) for peer-reviewed articles, clinical trials, GWAS, and meta-analyses to meet up the study's aim. Results: Epidemiologic studies reveal significant demographic variations, with POAG prevalent in African populations and PACG in East Asians. Key nonmodifiable risks include age, family history and ethnicity, while modifiable factors comprise elevated IOP, vascular dysregulation and lifestyle. Genetic studies implicate Conclusion: In this review, early screening, genetic screening, and specific interventions have been highlighted to combat the menace of glaucoma that results in a high global burden. Clinical significance: This comprehensive review enhances clinical practice by identifying high-risk populations for targeted screening and highlighting key genetic markers (e.g., How to cite this article: Hamid SAT, Abdulmajeed SM, Chowdhury IH,
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