ArticleNeurophotonics2026
Depth-sensitive assessment of cerebral blood flow and low-frequency oscillations after traumatic brain injury in mice using time-domain diffuse correlation spectroscopy.
Article in Neurophotonics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Traumatic brain injury (TBI) can lead to long-lasting impairments in cerebral perfusion, making early detection of microvascular changes critical for guiding clinical interventions. We employed time-domain diffuse correlation spectroscopy (TD-DCS) at 1064 nm to noninvasively quantify depth-resolved cerebral blood flow (CBF) and low-frequency oscillations (LFOs) in a mouse model of closed-head injury. By analyzing earlier photon arrivals (with greater superficial weighting) and later photon arrivals (with enhanced sensitivity to deeper tissue), we identified a significant drop in CBF shortly after injury, with partial recovery observed at 2 h post-trauma. Power spectral analysis of the blood flow index (BFI, a diffusion coefficient proportional to CBF) revealed significant alterations in LFO bands, particularly in slow-5 (0.01 to 0.027 Hz) and slow-3 (0.073 to 0.198 Hz) ranges. These differences, assessed using a paired Wilcoxon rank-sum test (
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