Evidence map›Paper›PMID 41523145›Full record

ReviewImmune network2025

Tissue-Resident ILC2s Across Organs: Heterogeneity, Niche Crosstalk, and Shared Regulatory Circuits.

Haksung Kim, Jangho Lim, Jongmin Baek, Steven J Van Dyken, Do-Hyun Kim

Abstract readReview
In one paragraph

Review in Immune network, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haksung KimDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.ORCID https://orcid.org/0009-0006-7363-9659
Jangho LimDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.ORCID https://orcid.org/0009-0004-0539-7999
Jongmin BaekDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.ORCID https://orcid.org/0009-0003-1068-6683
Steven J Van DykenDepartment of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-9787-0883
Do-Hyun KimDepartment of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.ORCID https://orcid.org/0000-0003-0160-3092

Funding

Defining the role of IL-18 in atopic dermatitisR01AI176660 · NIAID · WASHINGTON UNIVERSITY · PI Brian Kim, Steven Van Dyken · 2023 to 2026
$3.3M
NIAID NIH HHS R01 AI176660
6 · The paper itself

Abstract

Type 2 innate lymphoid cells (ILC2s) are an important source of innate cytokines that contribute to allergic inflammation. Recent studies have also suggested that ILC2s play a biological role in peripheral tissues such as lung, fat, intestine and skin, controlled by alarmins, neuropeptides and environmental factors. Furthermore, emerging studies have shown that tissues including the pancreas, uterus and meninges contain ILC2s that contribute to normal biological function. Here, we review recent studies on the physiological function of ILC2s in multiple tissues, emphasizing their importance not only in type 2 immune responses, but also in maintaining biological homeostasis.

Indexed as

AlarminBiological functionILC2Tissue homeostasis

Identifiers

PMID41523145
PMCPMC12780160

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.