ArticleTaiwan journal of ophthalmology
Therapeutic outcomes of oral cefcapene in meibomitis-related keratoconjunctivitis: A Propensity-matched cohort study.
Article in Taiwan journal of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThe purpose of the study was to evaluate the clinical characteristics and therapeutic response in patients with meibomitis-related keratoconjunctivitis (MRKC) who were treated with oral cefcapene pivoxil hydrochloride hydrate, and to determine factors associated with favorable outcomes. MATERIALS AND
methodsA retrospective analysis was conducted on 62 patients with MRKC, including 31 patients who received a 14-day course of oral cefcapene (100 mg three times daily) in combination with standard warm compression and lid hygiene. These patients were 1:1 propensity score-matched with 31 controls who underwent warm compression and lid hygiene, based on age, sex, meibomian gland expressibility, and meibum quality. Baseline characteristics and posttreatment outcomes - including corneal staining score (CSS) and ocular surface disease index (OSDI) - were compared between the groups.
resultsOne month after treatment, mean CSS was significantly lower in the cefcapene group (0.55 ± 0.65) compared with controls (0.86 ± 0.44,
conclusionAdjunctive use of short-term oral cefcapene therapy alongside standard eyelid hygiene measures resulted in a significant reduction in CSSs in patients with MRKC. However, this reduction was not accompanied by a statistically significant improvement in subjective symptoms.
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