Evidence map›Paper›PMID 41523083›Full record

ArticleHemaSphere2026

Daratumumab-based quadruplet for patients with extramedullary multiple myeloma: Results from the Phase II prospective EMN19 study.

Meral Beksac, Tulin Fıratlı Tuglular, Francesca Gay, Roberto Mina, Eirini Katodritou, Ali Unal, Michele Cavo, Guner Hayri Ozsan, Vincent H J van der Velden, Berna H Beverloo and 9 more

Abstract read
In one paragraph

Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Meral BeksacDepartment of Hematology Istinye University, Ankara Liv Hospital Ankara Turkey.ORCID https://orcid.org/0000-0003-1797-8657
Tulin Fıratlı TuglularDepartment of Hematology Marmara University Faculty of Medicine Istanbul Turkey.
Francesca GayUniversity of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino Torino Italy.
Roberto MinaUniversity of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino Torino Italy.
Eirini KatodritouDepartment of Hematology Theagenio Cancer Hospital Thessaloniki Greece.ORCID https://orcid.org/0000-0001-9404-807X
Ali UnalDepartment of Hematology, Faculty of Medicine Erciyes University Melikgazi Kayseri Turkey.
Michele CavoDepartment of Medical and Surgical Sciences University of Bologna Bologna Italy.
Guner Hayri OzsanDivision of Hematology-Oncology, Department of Internal Medicine, School of Medicine Dokuz Eylul University Izmir Turkey.
Vincent H J van der VeldenDepartment of Immunology, Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
Berna H BeverlooDepartment of Clinical Genetics, Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands.
Michael VermeulenDepartment of Hematology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands.
Mark van DuinDepartment of Hematology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands.
Guldane Cengiz SevalDepartment of Hematology Ankara University School of Medicine Ankara Turkey.
Omur Gokmen SevindikDepartment of Hematology Medipol University Istanbul Turkey.
Serena MeranteEuropean Myeloma Network Pavia Italy.
Kyriaki ManousouVeeda LifeSciences Dublin Ireland.
Peter SonneveldDepartment of Hematology Erasmus MC, University Medical Center Rotterdam Rotterdam The Netherlands.
Elena ZamagniIRCCS Azienda Ospedaliero-Universitaria di Bologna Istituto di Ematologia "Seràgnoli" Bologna Italy.
Evangelos TerposDepartment of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine Athens Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel therapies are needed for patients with multiple myeloma (MM) and extramedullary plasmacytomas. The prospective, Phase II EMN19 study assessed the efficacy and safety of daratumumab plus bortezomib, cyclophosphamide, and dexamethasone (DaraVCD) in 40 patients with newly diagnosed MM (NDMM;

Identifiers

PMID41523083
PMCPMC12780538

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.