Evidence map›Paper›PMID 41523066›Full record

ArticleJournal of pharmacy & bioallied sciences2025

Assessment of Promoter Hypermethylation in Tumor Suppressor Genes in Oral Leukoplakia and Oral Submucous Fibrosis.

Nishath S Abdul, Shubhangi Mhaske, Syed Afroz, Satyaprakash Nigam, Bhuvan Jyoti, Sasidhar Singaraju, Sahana Shivakumar, Shivakumar G Channaiah

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In one paragraph

Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nishath S AbdulFaculty of Oral Pathology, Department of OMFS and Diagnostic Sciences, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia.
Shubhangi MhaskeDepartment of Oral Pathology and Microbiology, People's College of Dental Sciences and Research Centre, Peoples University, Bhopal, Madhya Pradesh, India.
Syed AfrozDepartment of Oral Pathology and Microbiology, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.
Satyaprakash NigamDepartment of Oral and Maxillofacial Surgery, People's Dental Academy, Peoples University, Bhopal, Madhya Pradesh, India.
Bhuvan JyotiDepartment of Oral Medicine and Radiology, Ranchi Institute of Neuro-Psychiatry and Allied Sciences, Kanke, Ranchi, Jharkhand, India.
Sasidhar SingarajuOral Pathology and Microbiology, Rishiraj College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.
Sahana ShivakumarPublic Health Dentistry, People's College of Dental Sciences and Research Centre, Peoples University, Bhopal, Madhya Pradesh, India.
Shivakumar G ChannaiahDepartment of Oral Medicine and Radiology, People's College of Dental Sciences and Research Centre, Peoples University, Bhopal, Madhya Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Promoter hypermethylation of tumor suppressor genes is a hallmark of early carcinogenesis in oral lesions. Aim: To assess the methylation status of Methods: DNA extracted from tissue samples of 30 leukoplakia, 30 OSMF, and 20 healthy controls was analyzed using methylation-specific PCR. Results: Promoter hypermethylation was significantly higher in both patient groups compared to controls ( Conclusion: Aberrant promoter methylation may serve as an early molecular marker in oral precancerous conditions, aiding early intervention and risk stratification.

Indexed as

DNA methylationepigeneticsoral leukoplakiaOSMFtumor suppressor genes

Identifiers

PMID41523066
PMCPMC12788514

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.