ArticleJournal of pharmacy & bioallied sciences2025
Assessment of Cognitive Dysfunction and Quality of Recovery after General Anesthesia in Perimenopausal Women.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Perimenopausal women often experience neurocognitive fluctuations due to hormonal changes, which may predispose them to cognitive dysfunction following general anesthesia. The perioperative period presents a unique vulnerability to such patients, yet limited data exist on their cognitive outcomes and overall recovery quality. Methods: This prospective observational study included 120 perimenopausal women (age 45-55 years) scheduled for elective surgery under general anesthesia. Cognitive function was assessed using the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) preoperatively, on postoperative day 1 and day 7. Quality of recovery was evaluated using the QoR-15 scale. Descriptive and inferential statistics were applied, including paired Results: On postoperative day 1, the mean MMSE score decreased significantly from 28.7 ± 1.1 to 26.3 ± 1.6 ( Conclusion: Perimenopausal women exhibit significant early postoperative cognitive dysfunction and impaired quality of recovery after general anesthesia. Though partial cognitive and functional recovery occurs within a week, baseline levels are not fully restored.
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