ArticleJournal of pharmacy & bioallied sciences2025
Study on the Association of HPV Subtypes with Oral Squamous Cell Carcinoma.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
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Abstract
Background: Oral squamous cell carcinoma (OSCC) is a major public health concern with rising incidence globally. Human papillomavirus (HPV), particularly high-risk subtypes, has been implicated as a possible etiological factor, but the distribution and prevalence of specific subtypes in OSCC remain variable across populations. Methods: A cross-sectional analytical study was conducted on 120 histopathologically confirmed OSCC cases and 80 age- and sex-matched healthy controls. DNA was extracted from formalin-fixed paraffin-embedded tumor tissue and control oral mucosal scrapings. Polymerase chain reaction (PCR) with type-specific primers was used to detect HPV DNA. The identified HPV-positive samples were genotyped for subtypes 6, 11, 16, 18, 31, and 33. Statistical analysis was performed using Chi-square and logistic regression, with significance set at Results: Overall HPV positivity was significantly higher in OSCC cases (42.5%) than controls (11.3%) ( Conclusion: High-risk HPV subtypes, particularly HPV-16 and HPV-18, show a strong association with OSCC, highlighting the potential role of HPV vaccination and targeted screening programs in high-incidence regions.
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