ArticleJournal of pharmacy & bioallied sciences2025
Effect of Saline versus Gluconate/Acetate-Buffered Solution versus Lactate-Buffered Solution on Serum Chloride Among Children.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
Background: Intravenous (IV) fluid administration is routine in pediatric care, but fluid composition can significantly influence serum electrolyte levels. Hyperchloremia, often associated with 0.9% saline, may lead to metabolic acidosis and renal dysfunction. Balanced solutions, including gluconate/acetate-buffered and lactate-buffered fluids, are being explored for safer alternatives. Objective: To compare the effects of saline, gluconate/acetate-buffered, and lactate-buffered IV fluids on serum chloride levels in hospitalized children. Materials and Methods: A prospective observational study was conducted among pediatric in patients receiving one of three IV fluids: saline ( Results: Mean post-infusion chloride levels were significantly higher in the saline group (107.2 ± 3.1 mmol/L) compared to the gluconate/acetate group (103.5 ± 2.4 mmol/L) and lactate-buffered group (102.9 ± 2.8 mmol/L) ( Conclusion: Saline use in children is associated with greater increases in serum chloride compared to balanced solutions. Buffered fluids may be preferable for maintaining electrolyte stability in pediatric fluid therapy.
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