ArticleJournal of pharmacy & bioallied sciences2025
Assessment of Salivary Interleukin-6 and Cortisol Levels in Patients with Oral Lichen Planus: A Biochemical Correlation with Clinical Severity.
Article in Journal of pharmacy & bioallied sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Oral lichen planus (OLP) is a chronic inflammatory mucocutaneous disorder with autoimmune and psychosomatic implications. Recent studies suggest that pro-inflammatory cytokines and stress-related hormones may play a pivotal role in disease pathogenesis. Methods: A total of 60 participants were recruited, including 40 clinically and histopathologically confirmed OLP patients and 20 healthy controls. OLP patients were further categorized into mild ( Results: The mean salivary IL-6 levels were significantly higher in OLP patients (78.32 ± 18.56 pg/mL) compared to controls (32.45 ± 10.11 pg/mL, Conclusion: Elevated salivary IL-6 and cortisol levels in OLP patients correlate positively with clinical severity, supporting their potential role as noninvasive biomarkers for monitoring disease activity and psychological stress involvement in OLP pathogenesis.
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