ArticleInternational journal of biomedical imaging2026
The Impact of CT Reconstruction Parameters on Emphysema Index Quantification, HU-Based Measurements, and Goddard Score in COPD Assessment: A Prospective Study.
Article in International journal of biomedical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- The Impact of CT Reconstruction Parameters on Emphysema Index Quantification, HU-Based Measurements, and Goddard Score in COPD Assessment: A Prospective Study.International journal of biomedical imaging · 2026Article
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3 authors.
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Abstract
Background: Quantitative computed tomography (CT) plays a crucial role in assessing emphysema severity in chronic obstructive pulmonary disease (COPD). However, variations in CT reconstruction parameters-slice thickness (ST), kernel selection, field of view (FOV), and reconstruction gaps-can affect emphysema index (EI) quantification, impacting diagnostic accuracy and study comparability. Objective: This study examines how CT reconstruction parameters influence EI quantification using Hounsfield Unit (HU)-based measurements and the Goddard Score (GS) to refine imaging protocols for emphysema assessment. Methods: Low-dose CT scans were performed on 31 subjects, with images reconstructed using ST (0.6-10 mm), kernel settings (Br and Hr series), FOV ranges (250-370 mm), and reconstruction gaps (0.25-3 mm). EI was defined as the percentage of lung volume with attenuation values below - 950 HU, while GS provided a semi-quantitative assessment of emphysema severity. Statistical analyses evaluated the effects of reconstruction parameters on EI and GS. Results: Variations in FOV, kernel selection, and reconstruction gaps had negligible effects on the GS ( Conclusion: These findings confirm the reliability of CT-based emphysema quantification and highlight the importance of optimizing ST to balance sensitivity and image clarity. Standardized imaging protocols and AI-driven texture analysis could further enhance quantitative emphysema assessment, improving disease monitoring and therapeutic decision-making in COPD management.
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