ArticleEmergency medicine international2026
Prognostic Nutritional Index as a Novel Biomarker for Predicting Prognosis in Sepsis-Associated Encephalopathy: A Multicenter Retrospective Cohort Study.
Article in Emergency medicine international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Comparative Prognostic Accuracy of Objective Nutritional Indices in Critically Ill Patients with Sepsis: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Admission inflammatory and immuno-nutritional indices and in-hospital mortality in emergency department patients admitted to intensive care: a retrospective cohort study.Frontiers in medicine · 2026Article
- Prognostic Nutritional Index as a Novel Biomarker for Predicting Prognosis in Sepsis-Associated Encephalopathy: A Multicenter Retrospective Cohort Study.Emergency medicine international · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis-associated encephalopathy (SAE) has a high mortality rate with limited prognostic biomarkers. We investigated the relationship between the Prognostic Nutritional Index (PNI) and SAE outcomes. Methods: This multicenter cohort study (2008-2019) enrolled 3202 SAE patients. The primary outcome was 28-day all-cause mortality. Multivariable-adjusted analyses (logistic regression, propensity score matching, and inverse probability weighting) assessed PNI's prognostic value, supplemented by generalized additive models (GAMs), Kaplan-Meier, and ROC analyses. External validation was performed. Results: PNI independently predicted 28-day mortality (adjusted OR: 0.85; 95% CI: 0.77-0.93). The GAM identified PNI = 34 as the optimal prognostic threshold. Patients with PNI < 34 had higher 28-day mortality than those with PNI ≥ 34 in both original and validation cohorts ( Conclusions: This multicenter study establishes the PNI as an independent predictor of 28-day mortality in patients with SAE. We identified that SAE patients with PNI < 34 exhibited significantly higher 28-day mortality rates and worse neurological function.
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