Evidence map›Paper›PMID 41522674›Full record

ArticleTremor and other hyperkinetic movements (New York, N.Y.)2026

Underlying Tremor Improvement with Consistent Use of Transcutaneous Afferent Patterned Stimulation in Patients with Essential Tremor.

Stuart H Isaacson, Elizabeth Peckham, Winona Tse, Melita T Petrossian, Michael J Soileau, Mark Lew, Cameron Dietiker, Nijee Luthra, Pinky Agarwal, Rohit Dhall and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Tremor and other hyperkinetic movements (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Stuart H IsaacsonParkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton, FL, USA.ORCID 0000-0002-9914-5706
Elizabeth PeckhamCentral Texas Neurology Consultants, Round Rock, TX, USA.
Winona TseDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8527-0936
Melita T PetrossianPacific Neuroscience Institute, Pacific Movement Disorders Center, Santa Monica, CA, USA.ORCID 0000-0002-3948-9638
Michael J SoileauTexas Movement Disorder Specialists, Georgetown, TX, USA.ORCID 0000-0002-3944-1327
Mark LewDepartment of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA.
Cameron DietikerDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1421-4440
Nijee LuthraDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6774-0711
Pinky AgarwalBooth Gardner Parkinson's Center, Evergreen Health, Kirkland, WA, USA.ORCID 0009-0001-1022-1398
Rohit DhallMovement Disorders Clinic, University of Arkansas for Medical Sciences, Little Rock, AR, USA.ORCID 0000-0001-9436-1920
John MorganDepartment of Neurology, Augusta University, Augusta, GA, USA.
Ejaz A ShamimMid-Atlantic Kaiser Permanente Neuroscience Institute, Kaiser Permanente Mid-Atlantic States, Rockville, MD, USA.ORCID 0000-0003-0992-056X
Holly A ShillBarrow Neurological Institute, University of Arizona, Phoenix, AZ, USA.ORCID 0000-0003-1284-5038
Fernando L PaganDepartment of Neurology, Georgetown University Hospital, Washington, DC, USA.
Pravin KhemaniDepartment of Neurology, Swedish Neuroscience Institute, Seattle, WA, USA.ORCID 0000-0003-3579-9230
Jessica TateDepartment of Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Lan LuoDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1314-4367
William OndoDepartment of Neurology, Houston Methodist Neurological Institute, Houston, TX, USA.ORCID 0000-0001-6090-4261
Mark HallettHuman Motor Control Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.ORCID 0000-0002-3180-6811
Chiahao LuCala Health, San Mateo, CA, USA.ORCID 0000-0002-6356-7253
Kathryn H RosenbluthCala Health, San Mateo, CA, USA.ORCID 0000-0002-7923-0559
Scott L DelpDepartment of Bioengineering and Mechanical Engineering, Stanford University, Palo Alto, CA, USA.ORCID 0000-0002-9643-7551
Rajesh PahwaDepartment of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-3176-6466

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Transcutaneous afferent patterned stimulation (TAPS) is a non-invasive, wrist-worn neurostimulation therapy that has demonstrated acute and short-term lasting tremor reduction in patients with essential tremor (ET). However, the longer-term improvement in underlying tremor severity from consistent use of TAPS has not been fully explored. Methods: We conducted a retrospective analysis of the multicenter PROSPECT trial, which evaluated twice-daily TAPS use over three months in patients with ET. Underlying tremor improvement was assessed by comparing pre-stimulation tremor severity at baseline with pre-stimulation tremor severity at 1- and 3-month follow-up visits. Tremor severity was measured using the Bain & Findley Activities of Daily Living (BF-ADL) scale and the Tremor Research Group's Essential Tremor Rating Assessment Scale (TETRAS). Responders were defined as patients demonstrating at least a 1-point improvement on any qualifying task. Results: Among 192 patients with available data, pre-stimulation BF-ADL scores improved significantly by 2.0 points at 1 month and 2.7 points at 3 months compared with baseline (p < 0.001). Pre-stimulation TETRAS scores also showed significant improvements at both time points (p < 0.001). Measurements at 1 and 3 months were made an average of 16.2 hours after the prior stimulation session. Over 80% of patients met responder criteria for underlying tremor improvement on BF-ADL and TETRAS at both follow-up visits. Improvements were observed even among patients using TAPS approximately once daily. Conclusions: Consistent use of TAPS was associated with significant improvement in underlying tremor severity in patients with essential tremor. These findings suggest that regular TAPS use may confer sustained therapeutic benefit.

Indexed as

Essential TremorTranscutaneous Electric Nerve StimulationActivities of Daily LivingAgedAged, 80 and overFemaleHumansMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexTreatment Outcomeneuromodulationtranscutaneous afferent patterned stimulationtremorunderlying tremor improvement

Identifiers

PMID41522674
PMCPMC12785663

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.