ArticleJBMR plus2026
Crohn's and bones: assessing bone microarchitecture using high-resolution peripheral quantitative computed tomography.
Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Crohn's disease (CD) is known to negatively affect BMD and inflammatory (non-stricture) and stricturing CD are the two common phenotypes. Studies exploring CD phenotypes with advanced imaging techniques, such as HR-pQCT, are lacking. Therefore, the aim of this cross-sectional study was to examine differences in bone quality, including volumetric BMD, bone microarchitecture, bone geometry, estimated bone strength, and void spaces, between inflammatory and stricturing CD phenotypes using HR-pQCT. Participants aged 55 yr and over were recruited and scanned by HR-pQCT (XtremeCT II) at the distal radius and tibia. Finite element analysis estimated bone strength and void space analysis captured structural inhomogeneities in the trabecular compartment. Health history and CD-specific information were assessed with blood work and questionaries. Two-way ANOVA, with sex as a factor, compared CD phenotypes. Sixty-one participants were recruited (52% female, mean age: 65.3 ± 6.1 yr). Group-by-sex interactions were observed at the tibia. Specifically, males in the stricturing group exhibited a smaller cortical bone area than males in the inflammation group, while no differences were detected between groups for females (
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