ArticleJournal of pharmacy & bioallied sciences
Hippocampal Beta-Amyloid Accumulation In Aluminium Chloride and D-Galactose-Induced Rats: Establishing a Nontransgenic Alzheimer's Model.
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Rodent Models of Alzheimer's Disease: Bridging the Translational Gap Through Systems-Level Integration.Biomedicines · 2026Review
- Targeting the Redox-NF-κB/NLRP3 axis with intranasal liposomal minocycline mitigates aluminum-induced cognitive and structural deficits.Molecular biology reports · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Alzheimer's disease (AD) is characterized by tau protein aggregation and beta-amyloid (Aβ) plaques leading to progressive cognitive decline. Nontransgenic models using aluminium chloride (AlCl Objective: To investigate beta-amyloid accumulation in the hippocampal CA2 region using a nontransgenic rat model of AD made by combined AlCl Methods: Twelve adults male Wistar rats were divided into control ( Results: Immunohistochemical analysis revealed marked beta-amyloid immunoreactivity in the model group, with dense extracellular and intracellular deposits distributed throughout the CA2 subfield. The control group showed minimal beta-amyloid staining without plaques, confirming the specificity of the observed pathology. Conclusion: Combined AlCl
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