ArticleJournal of pharmacy & bioallied sciences
Development and Physical Characterization of Injectable Nanocrystals Derived from
Article in Journal of pharmacy & bioallied sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Despite its ornamental value, Objective: This study investigates the pharmaceutical potential of plant-derived nanoparticles, specifically NCs produced from the stem SAP of Methods: The milky SAP from the stem of Euphorbia fractiflexa was collected and processed to produce NCs. The NCs were analyzed by dynamic light scattering (DLS) for their zeta potential, particle size and polydispersity index (PDI). Morphological analysis was performed using scanning electron microscopy (SEM). The antibacterial activity of the NCs was evaluated against Gram-positive and Gram-negative bacterial strains using the agar well diffusion method, with ciprofloxacin as a standard reference. A statistical analysis was performed to compare the antibacterial activity of the NCs with the standard. Results: The NCs exhibited a zeta potential of - 7.62 ± 8.83 mV, indicating moderate stability, with particle sizes ranging from 100 to 200 nm, making them suitable for injectable applications. SEM revealed irregular, inhomogeneous crystal structures. The NCs showed significant antibacterial activity and inhibited both Gram-positive and Gram-negative bacteria with inhibition zones of 18 - 21.3 µm varied with individual bacteria. Although Conclusion: This study highlights
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