Evidence map›Paper›PMID 41522494›Full record

ArticlePeerJ2026

Zmpste24 deficiency contributes to intervertebral disc degeneration by undermining the stability of the nuclear membrane of nucleus pulposus cells.

Chen Han, Shaotian Fu, Hanyi Wang, Kai Zhang, Jie Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chen Han *Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China.
Shaotian Fu *Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China.
Hanyi WangShanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Kai ZhangShanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China.
Jie ZhaoShanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD) is often accompanied by the senescence of nucleus pulposus (NP) cells and narrowed intervertebral disc space. Zinc metalloproteinase STE24 (Zmpste24), a common anti-aging gene, has been studied in several diseases but remains understudied in IVDD. This study aimed to investigate the relationship between IVDD and alterations in Zmpste24 expression. Immunohistochemical staining revealed that reduced Zmpste24 expression in patients with IVDD.

Indexed as

Intervertebral Disc DegenerationMembrane ProteinsMetalloendopeptidasesNucleus PulposusAnimalsCells, CulturedCellular SenescenceHumansMaleMiceMice, KnockoutRatsRats, Sprague-DawleyMembrane ProteinsMetalloendopeptidasesZMPSTE24 protein, humanZmpste24 protein, mouseInflammationIntervertebral discIntervertebral disc degenerationMechanical stressNuclear membraneNucleusNucleus pulposus cellsSenescenceZmpste24Zmpste24 KO mice

Identifiers

PMID41522494
PMCPMC12790285

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.