Evidence map›Paper›PMID 41522471›Full record

ArticleMedComm2026

Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations.

Junho Kang, Dong Min Lim, Young-Joon Kim, Hyeran Shim, Tae-You Kim, Kyu Joo Park, Sung-Bum Kang, Chang Sik Yu, Jong Lyul Lee, Yeuni Yu and 20 more

Abstract read
In one paragraph

Article in MedComm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Junho KangDepartment of Research Keimyung University Dongsan Medical Center Daegu Republic of Korea.
Dong Min LimMedical Research Institute Pusan National University Yangsan Republic of Korea.
Young-Joon KimDepartment of Biochemistry, College of Life Science and Biotechnology Yonsei University Seoul Republic of Korea.
Hyeran ShimDepartment of Biochemistry, College of Life Science and Biotechnology Yonsei University Seoul Republic of Korea.
Tae-You KimDepartment of Internal Medicine Seoul National University College of Medicine Seoul National University Hospital Seoul Republic of Korea.
Kyu Joo ParkDepartment of Surgery, Seoul National University Hospital Seoul National University College of Medicine Seoul Republic of Korea.
Sung-Bum KangDepartment of Surgery, Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Republic of Korea.
Chang Sik YuDepartment of Surgery, Division of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center Seoul Republic of Korea.
Jong Lyul LeeDepartment of Surgery, Division of Colon and Rectal Surgery University of Ulsan College of Medicine and Asan Medical Center Seoul Republic of Korea.
Yeuni YuMedical Research Institute Pusan National University Yangsan Republic of Korea.
Hansong LeeMedical Research Institute Pusan National University Yangsan Republic of Korea.
Eun Jung KwonMedical Research Institute Pusan National University Yangsan Republic of Korea.
Hyo Min KimDepartment of Convergence Medicine, School of Medicine Pusan National University Yangsan Republic of Korea.
Seongik MunDepartment of Convergence Medicine, School of Medicine Pusan National University Yangsan Republic of Korea.
Donghee KwakDepartment of Convergence Medicine, School of Medicine Pusan National University Yangsan Republic of Korea.
Hae Seul LeeDepartment of Convergence Medicine, School of Medicine Pusan National University Yangsan Republic of Korea.
Hye Jin HeoDepartment of anatomy, School of Medicine Pusan National University Yangsan Republic of Korea.
Eun Kyoung KimDepartment of anatomy, School of Medicine Pusan National University Yangsan Republic of Korea.
Seung Eun BaekDepartment of anatomy, School of Medicine Pusan National University Yangsan Republic of Korea.
Jong-Wook ParkDepartment of Immunology, School of Medicine Keimyung University Daegu Republic of Korea.
Sung Uk BaeInstitute of Medical Science Keimyung University Daegu Republic of Korea.
Taeg Kyu KwonDepartment of Immunology, School of Medicine Keimyung University Daegu Republic of Korea.
Dongjun LeeDepartment of Convergence Medicine, School of Medicine Pusan National University Yangsan Republic of Korea.
Kihun KimDepartment of Occupational and Environmental Medicine Pusan National University Yangsan Hospital Yangsan Republic of Korea.
Chang-Kyu OhDepartment of Biochemistry, School of Medicine Pusan National University Yangsan Republic of Korea.
Dai Sik KoDivision of Vascular Surgery, Department of General Surgery Gachon University Gil Medical Center Incheon Republic of Korea.
Sunghwan ChoDepartment of Surgery Pusan National University Yangsan Hospital Yangsan Republic of Korea.
Hae Ryoun ParkDepartment of Oral Pathology, School of Dentistry Pusan National University Yangsan Republic of Korea.
Shin KimDepartment of Research Keimyung University Dongsan Medical Center Daegu Republic of Korea.
Yun Hak KimDepartment of Convergence Medicine, School of Medicine Pusan National University Yangsan Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) ranks as the third leading cause of cancer-related deaths worldwide, characterized by genomic heterogeneity arising from ethnic and interindividual differences. Producing region-specific data to characterize ethnic-specific somatic mutations is essential for advancing CRC research. Additionally, accurate somatic mutation detection requires paired tissue analyses to account for interindividual diversity. This study aims to highlight the importance of ethnic diversity in shaping CRC's genomic landscape and emphasize the necessity for region-specific data to refine diagnostic and therapeutic approaches. This study emphasizes the need for region-specific data by analyzing an unprecedented 197 paired samples from the Korean CRC cohort through whole-genome sequencing. We identified 78 potential driver genes. Notably,

Indexed as

colorectal cancermicrosatellite instabilitymutational hotspotstumor mutational burdenwhole‐genome sequencing

Identifiers

PMID41522471
PMCPMC12783921

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.