Evidence map›Paper›PMID 41522467›Full record

ArticleNPJ dementia2026

The proportion of Alzheimer's disease attributable to apolipoprotein E.

Dylan M Williams, Sami Heikkinen, Mikko Hiltunen, FinnGen, Neil M Davies, Emma L Anderson

Registry-linked trialAbstract read
In one paragraph

Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07679906 (ALZEVIT), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07679906 recruitingnot on this map

ALZEVIT: A Nationwide Decentralized Digital Cohort for Population APOE Genotyping, Longitudinal Characterization of APOE ε4/ε4 Trajectories, and Trial-readiness for Precision Prevention in Early Alzheimer's Disease

TypeobservationalSponsorFiralis SARan2026 to 2028Enrolled50,000ConditionsAlzheimer
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. An introduction to polygenic scores - methodological basics and recent advances.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026
    Article
  5. Review
  6. Review
  7. Plasma proteomics ofmedRxiv : the preprint server for health sciences · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dylan M WilliamsDivision of Psychiatry, University College London, Maple House, 149 Tottenham Court Rd, London, W1T 7NF UK.
Sami HeikkinenInstitute of Biomedicine, University of Eastern Finland, Yliopistonranta 8, Kuopio, P.O. Box 1627, FI-70211 Finland.
Mikko HiltunenInstitute of Biomedicine, University of Eastern Finland, Yliopistonranta 8, Kuopio, P.O. Box 1627, FI-70211 Finland.
FinnGen
Neil M DaviesDivision of Psychiatry, University College London, Maple House, 149 Tottenham Court Rd, London, W1T 7NF UK.
Emma L AndersonDivision of Psychiatry, University College London, Maple House, 149 Tottenham Court Rd, London, W1T 7NF UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variation in the

Indexed as

DiseasesGeneticsMedical researchNeurologyNeuroscienceRisk factors

Identifiers

PMID41522467
PMCPMC12789039

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.