Evidence map›Paper›PMID 41522420›Full record

ArticleClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology2026

Clinical features of neonatal Graves' disease revealed by twelve cases that require- antithyroid therapy.

Eriko Adachi, Ryosei Iemura, Yumi Tanaka, Hisae Nakatani, Ryuichi Nakagawa, Yuichi Miyakawa, Akito Sutani, Kei Takasawa, Makoto Ono, Takeru Yamauchi and 4 more

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Article in Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Eriko AdachiDepartment of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.
Ryosei IemuraDepartment of Neonatal Medicine, Kawaguchi Municipal Medical Center, Kawaguchi, Japan.
Yumi TanakaDepartment of Neonatology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Hisae NakataniDepartment of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.
Ryuichi NakagawaDepartment of Pediatrics, Musashino Red Cross Hospital, Tokyo, Japan.
Yuichi MiyakawaDepartment of Neonatal Medicine, Kawaguchi Municipal Medical Center, Kawaguchi, Japan.
Akito SutaniDepartment of Neonatal Medicine, Kawaguchi Municipal Medical Center, Kawaguchi, Japan.
Kei TakasawaDepartment of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.
Makoto OnoDepartment of Pediatrics, Tokyobay UrayasuIchikawa Medical Center, Urayasu, Japan.
Takeru YamauchiDepartment of Neonatology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan.
Manabu SugieDepartment of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.
Yoshihiro MinosakiDepartment of Neonatal Medicine, Kawaguchi Municipal Medical Center, Kawaguchi, Japan.
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.
Kenichi KashimadaDepartment of Pediatrics and Developmental Biology, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonatal Graves' disease (GD) is rare and serious condition with a complicated clinical course, its details of the clinical features have not been clarified. This study aimed to clarify the clinical course of neonatal GD cases requiring anti-thyroid treatment. We retrospectively analyzed records from 12 neonates (7 males) diagnosed with GD from 2012 to 2021. All neonates had maternal histories of GD, with significantly elevated TRAb levels (≥ 19 IU/L) observed during the second or third trimester of pregnancy. At birth, TRAb levels were elevated in all neonates (≥ 17.4 IU/L). Thiamazole (MMI) was given to 11 neonates, with additional potassium iodide (KI) and/or β-blockers in 10 cases; one received only KI and a β-blocker. Notably, maternal TRAb levels during late pregnancy were significantly correlated with neonatal TRAb levels at birth (R

Indexed as

hyperthyroidismneonatal Graves’ diseasesecondary central hypothyroidismTRAb

Identifiers

PMID41522420
PMCPMC12779499

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.