ReviewPakistan journal of medical sciences2025
Impact of type of anaesthesia on long-term outcomes in glioma patients undergoing craniotomy: A systematic review.
Review in Pakistan journal of medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Propofol and Glioblastoma Biology: A Narrative Review of Perioperative Clinical Evidence and PI3K/AKT-Wnt-miRNA, GABA-A, and Immune-Checkpoint Pathways.BioMed research international · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To assess the effects of volatile and intravenous anaesthetic agents on long-term outcomes in patients with glioma, undergoing tumour resection. Methodology: This systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Two databases were searched from inception until January 2025, namely PubMed/MEDLINE and EMBASE using MeSH terms for anaesthesia and glioma. Six retrospective cohort studies were selected for data extraction after thoroughly reviewing the database search results against pre-determined inclusion and exclusion criteria. The quality assessment was done as per National Heart, Lung and Blood institute checklist for observational studies. Results: A total of six retrospective cohort studies conducted between 2017 and 2021 were reviewed. These included both sexes, predominantly aged over 18 years, except for one study that enrolled patients as young as 16. Five studies concluded that the type of anaesthesia had no effect on survival or recurrence. Only one associated propofol with increased progression free survival (PFS) and overall survival (OS). While rest of the studies showed no effect, Dong et al. suggested that sevoflurane may reduce OS in patients with Karnofsky Performance Status (KPS) <80. Overall, the type of general anaesthesia drugs did not affect five-year PFS rate. Conclusion: We found no impact of anaesthetic agent on glioma outcomes in majority of studies, but the literature suggesting potential tumour-modulating effects of these drugs is significant enough to warrant further studies. Similar associations exist in other cancers. Well-designed RCTs are crucial to clarify if anaesthetic agents affect long-term survival and oncological outcomes in glioma patients.
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Registered trials
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