Evidence map›Paper›PMID 41522351›Full record

ArticleInternational journal of biological sciences2026

Impact of rare JAK/STAT germline mutations on vaccination-induced innate immune responses in a Tyrolian population.

Lothar Hennighausen, Gyuhyeok Cho, Sung-Gwon Lee, Yasmin Caf, Jungwook Kim, Ludwig Knabl, Priscilla A Furth, Hye Kyung Lee

Abstract read
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In one paragraph

Article in International journal of biological sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lothar HennighausenSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Gyuhyeok ChoDepartment of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
Sung-Gwon LeeSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Yasmin CafY2L2Science GmbH, Zams, Austria.
Jungwook KimDepartment of Chemistry, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.
Ludwig KnablY2L2Science GmbH, Zams, Austria.
Priscilla A FurthSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.
Hye Kyung LeeSection of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, US National Institutes of Health, Bethesda, Maryland 20892, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccination triggers the release of pro-inflammatory cytokines, the stimulation of the Janus Kinase (JAK) - Signal Transducer and Activator of Transcription (STAT) pathway and the activation of interferon response genes. While some JAK/STAT variants are associated with hematopoietic malignancies, the impact of the vast majority is unknown. Here we identify JAK/STAT germline variants in a Tyrolian cohort, including octogenarians, and link specific rare variants to enhanced vaccine-induced interferon transcriptomic responses. AlphaFold 3 predicted conformational changes in JAK and STATs variants, impacting their interactions and formation of receptor complexes. We also identified co-occurring variants in TYK2 and other modulators of interferon signaling that possibly modify the impact of JAK and STAT variants in the innate immune response. Our results demonstrate that the vaccine-induced innate immune transcriptomic response can be used for an

Indexed as

Germ-Line MutationImmunity, InnateJanus KinasesSTAT Transcription FactorsHumansSignal TransductionVaccinationJanus KinasesSTAT Transcription Factors

Identifiers

PMID41522351
PMCPMC12780842

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.