ArticleInternational journal of clinical and experimental pathology2025
Thrombus formation in cancer patients using autopsy materials: an immunohistochemical analysis.
Article in International journal of clinical and experimental pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCancer-associated thrombosis (CAT) is a well-known complication of malignant tumors. It has been predominantly reported in mucin (MUC)-producing adenocarcinomas, with MUC secreted by the tumor thought to be involved in the thrombotic mechanism. However, studies comparing tumor and thrombus areas are scarce.
methodsIn this study, we examined the immunohistochemical characteristics of 18 autopsy specimens of tumor and thrombus sections (CAT) and control specimens of 25 tumors without thrombus and 16 thrombi without tumors. Immunohistochemistry was performed using antibodies associated with coagulation and MUC, including tissue factor (TF), thrombin, MUC2, MUC5AC, and MUC6.
resultsIt was revealed that TF was predominantly positive in the tumor sections of CAT compared with tumors without thrombus (
conclusionsThese results suggest that the expression of TF in tumor tissues is involved in the pathogenesis of CAT, and furthermore, that MUC2 contributes to thrombus formation in CAT via a pathway other than TF. In the future, these immunohistochemical analyses will help predict CAT in cancers and detect hidden cancers in patients with thrombosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.