Evidence map›Paper›PMID 41522211›Full record

ArticleNature physics2025

Topological interactions drive the first fate decision in the

Woonyung Hur, Arghyadip Mukherjee, Luke Hayden, Ziqi Lu, Anna Chao, Noah P Mitchell, Sebastian J Streichan, Massimo Vergassola, Stefano Di Talia

Abstract read
In one paragraph

Article in Nature physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Positional information and information flows in dynamic tissues.bioRxiv : the preprint server for biology · 2026
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Woonyung HurDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Arghyadip MukherjeeLaboratoire de physique de l'Ecole Normale Superieure, CNRS, PSL Research University, Sorbonne Universite, Paris, France.
Luke HaydenDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Ziqi LuDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Anna ChaoDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.
Noah P MitchellKavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, USA.
Sebastian J StreichanKavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, USA.
Massimo VergassolaLaboratoire de physique de l'Ecole Normale Superieure, CNRS, PSL Research University, Sorbonne Universite, Paris, France.
Stefano Di TaliaDepartment of Cell Biology, Duke University School of Medicine, Durham, NC, USA.

Funding

Time-keeping mechanisms of embryonic cell cyclesR01GM122936 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2017 to 2023
$2.0M
Physical principles of early Drosophila embryogenesisR35GM153490 · NIGMS · DUKE UNIVERSITY · PI Stefano Di Talia · 2024 to 2026
$1.5M
Mechanisms and developmental functions of cytoplasmic flows in early embryogenesisR01GM136763 · NIGMS · DUKE UNIVERSITY · PI DI TALIA, STEFANO · 2021 to 2023
$1.1M
Decoding the mechanical interactions between tissue layers sculpting organ shapeK99HD110675 · NICHD · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MITCHELL, NOAH PRENTICE · 2023 to 2023
$142k
NICHD NIH HHS K99 HD110675NIGMS NIH HHS R01 GM122936NIGMS NIH HHS R01 GM136763NIGMS NIH HHS R35 GM153490
6 · The paper itself

Abstract

During embryogenesis, the first cell fate decision - whether the cell participates in development of the embryo or not - is often linked to the positioning of the nucleus. The cell cycle oscillator and associated cytoskeletal dynamics contribute to the control of nuclear positioning. Yet, the mechanisms that ensure that the correct number of nuclei move to their appropriate place remain poorly understood. Here, we show that the orientation of the mitotic spindle controls the first fate decision in

Identifiers

PMID41522211
PMCPMC12782591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.