Evidence map›Paper›PMID 41522195›Full record

ArticleInternet of things (Amsterdam, Netherlands)2025

A feedback-driven brain organoid platform enables automated maintenance and high-resolution neural activity monitoring.

Kateryna Voitiuk, Spencer T Seiler, Mirella Pessoa de Melo, Jinghui Geng, Tjitse van der Molen, Sebastian Hernandez, Hunter E Schweiger, Jess L Sevetson, David F Parks, Ash Robbins and 8 more

Abstract read
In one paragraph

Article in Internet of things (Amsterdam, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Incubator-Free Organoid Culture in a Sealed Recirculatory System.bioRxiv : the preprint server for biology · 2025
    Article
  13. Review
  14. Automated Optofluidic Analysis of Single Extracellular Vesicles for Organoid Culture Monitoring.IEEE journal of selected topics in quantum electronics : a publication of the IEEE Lasers and Electro-optics Society
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Kateryna VoitiukGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-6392-5188
Spencer T SeilerGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-0087-1346
Mirella Pessoa de MeloGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.
Jinghui GengGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-3431-9568
Tjitse van der MolenNeuroscience Research Institute, University of California Santa Barbara, Santa Barbara, 93106, CA, USA.ORCID 0000-0001-6147-542X
Sebastian HernandezGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.
Hunter E SchweigerGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0003-0399-9481
Jess L SevetsonGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0001-7434-1447
David F ParksGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-4635-8206
Ash RobbinsGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-5556-8547
Sebastian Torres-MontoyaGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-4900-7161
Drew EhrlichGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0001-6794-6800
Matthew A T ElliottGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0001-6313-6819
Tal SharfGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-7899-2818
David HausslerGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0003-1533-4575
Mohammed A Mostajo-RadjiGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0002-1634-7514
Sofie R SalamaGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0001-6999-7193
Mircea TeodorescuGenomics Institute, University of California Santa Cruz, Santa Cruz, 95064, CA, USA.ORCID 0000-0001-7085-5248

Funding

Nanoparticle Tracking Analyzer (NTA) for the Center for Live Cell GenomicsRM1HG011543 · NHGRI · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI HAUSSLER, DAVID H, SALAMA, SOFIE REDA · 2021 to 2025
$12.0M
Data Resource and Administrative Coordination Center for the Scalable and Systematic Neurobiology of Psychiatric and Neurodevelopmental Disorder Risk Genes ConsortiumU24MH132628 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI DAVID H HAUSSLER, Tomasz Nowakowski · 2023 to 2026
$7.9M
IRACDA at UCSC and CSUMBK12GM139185 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI FORSBERG, CAMILLA, HINCK, LINDSAY E · 2020 to 2024
$4.1M
Dissecting the role of NOTCH2NL genes in human brain development and neurological disorders associated with chromosome 1q21.1 distal duplications and deletions.R01MH120295 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI SALAMA, SOFIE REDA · 2020 to 2024
$3.7M
NHGRI NIH HHS RM1 HG011543NIGMS NIH HHS K12 GM139185NIMH NIH HHS R01 MH120295NIMH NIH HHS U24 MH132628
6 · The paper itself

Abstract

The analysis of tissue cultures requires a sophisticated integration and coordination of multiple technologies for monitoring and measuring. We have developed an automated research platform enabling independent devices to achieve collaborative objectives for feedback-driven cell culture studies. Our approach enables continuous, communicative, non-invasive interactions within an Internet of Things (IoT) architecture among various sensing and actuation devices, achieving precisely timed control of

Indexed as

BiotechnologyBrain organoidCloud biologyInternet of thingsNeural developmentStem cells

Identifiers

PMID41522195
PMCPMC12781996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.