Evidence map›Paper›PMID 41522161›Full record

ArticleJournal of thoracic disease2025

Postoperative innate immune function after minimally invasive transcervical esophagectomy (MICE) versus minimally invasive transthoracic esophagectomy (MIE).

Lotte M C Jacobs, Luuk D Drager, Leo A B Joosten, Lucas T van Eijk, Merlijn Hutteman, Baukje van den Heuvel, Cornelis J H M van Laarhoven, Michiel C Warlé, Bastiaan R Klarenbeek

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In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lotte M C JacobsDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Luuk D DragerDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Leo A B JoostenDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
Lucas T van EijkDepartment of Anaesthesiology, Radboud University Medical Center, Nijmegen, The Netherlands.
Merlijn HuttemanDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Baukje van den HeuvelDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Cornelis J H M van LaarhovenDepartment of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Michiel C Warlé *Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.
Bastiaan R Klarenbeek *Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Recently, the minimally invasive transcervical esophagectomy (MICE) technique was introduced as a new approach for esophagectomy. The aim of this explorative study was to compare the effects of minimally invasive transthoracic esophagectomy (MIE), the most commonly used esophagectomy technique, versus MICE on postoperative immune function. Methods: For this explorative cohort study, data regarding 42 F4S PREHAB trial participants (NL8699, International Clinical Trials Registry Platform) were analyzed. Immune function was assessed preoperatively and on postoperative day 1 (POD1) via plasma cytokines [interleukin (IL)-6, tumor necrosis factor (TNF), and IL-10], damage-associated molecular patterns (DAMPs) (S100A8/A9 and S100A12), and the Olink targeted proteomics inflammation panel. Results: Concentrations of circulating cytokines and DAMPs, Conclusions: This explorative study found no differences in postoperative inflammatory status between the two procedures. Limited statistical power and sample size warrant larger trials to further investigate potential differences in postoperative immune response and clinically relevant outcomes.

Indexed as

Esophagectomyimmunologyinflammationminimally invasive surgery

Identifiers

PMID41522161
PMCPMC12780412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.