Evidence map›Paper›PMID 41522107›Full record

ArticleJournal of thoracic disease2025

Persistent and unstable eosinophil levels in the sputum and blood: impact on the clinical prognosis of patients with chronic obstructive pulmonary disease.

Jieqi Peng, Xiaohui Wu, Xiang Wen, Zhishan Deng, Fan Wu, Gaoying Tang, Qi Wan, Cuiqiong Dai, Kunning Zhou, Lifei Lu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jieqi Peng *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-9638-4015
Xiaohui Wu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiang Wen *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zhishan DengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Fan WuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Gaoying TangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qi WanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Cuiqiong DaiState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Kunning ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Lifei LuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Shengtang ChenDepartment of Radiology, Wengyuan County People's Hospital, Shaoguan, China.
Changli YangDepartment of Pulmonary Medicine, Wengyuan County People's Hospital, Shaoguan, China.
Yongqing HuangIntensive Care Unit, Lianping County People's Hospital, Heyuan, China.
Shuqing YuDepartment of Pulmonary Medicine, Lianping County People's Hospital & Lianping County Second People's Hospital, Heyuan, China.
Pixin RanState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-6651-634X
Yumin ZhouState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0002-0555-8391

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with chronic obstructive pulmonary disease (COPD) with eosinophilia exhibit poor lung function. However, the prognostic impact of eosinophilia remains unclear. This study evaluates the relationship between sputum and blood eosinophil variability and the long-term clinical outcomes of COPD. Methods: Sputum eosinophil proportion ≥3% and blood eosinophil count ≥300 cells/µL were considered high. Based on sputum/blood eosinophil levels at baseline and at the 3-year follow-up, patients with COPD were divided into the persistently low, unstable, and persistently high sputum/blood eosinophils groups. Poisson regression was used to assess acute exacerbation risk, and mixed-effects models were used to evaluate lung function decline. Results: Compared with the persistently low sputum eosinophils group (n=183), the persistently high sputum eosinophils group (n=68) had more dyspnea and had a higher modified Medical Research Council score, poorer baseline lung function, and experienced more total exacerbations [adjusted relative risk (RR) 1.47, 95% confidence interval (CI): 1.21-1.80, P<0.001] and more moderate-to-severe exacerbations [adjusted RR 1.62, 95% CI: 1.25-2.10, P<0.001]. The unstable sputum eosinophils group (n=122) experienced more total exacerbations (adjusted RR 1.47, 95% CI: 1.24-1.75, P<0.001) and more moderate-to-severe exacerbations (adjusted RR 1.29, 95% CI: 1.02-1.63, P=0.03). Similarly, the persistently high blood eosinophils group experienced more total exacerbations than the persistently low blood eosinophils group (adjusted RR 1.27, 95% CI: 1.05-1.54, P=0.02), the unstable blood eosinophils group experienced more total exacerbations (adjusted RR 1.27, 95% CI: 1.07-1.51, P=0.008) and more moderate-to-severe exacerbations (adjusted RR 1.29, 95% CI: 1.03-1.62, P=0.03). There were no significant differences in lung function decline. Conclusions: Persistent eosinophil elevation was associated with a higher exacerbation risk.

Indexed as

Chronic obstructive pulmonary disease (COPD)eosinophilexacerbationlung function decline

Identifiers

PMID41522107
PMCPMC12780449

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.