Evidence map›Paper›PMID 41522102›Full record

ArticleJournal of thoracic disease2025

Minimally invasive

Jared P Beller, Linda W Martin, Ryan Hall, Peter Tatum, Joseph D Phillips, Kayla A Fay, Rachel Williams, Joshua Boys, Betul Gundogdu, Matthew Elliot and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jared P Beller *Division of Cardiothoracic Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Linda W Martin *Division of Cardiothoracic Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Ryan HallDepartment of Surgery, Tufts University, Boston, MA, USA.
Peter TatumDepartment of Neurology, Tufts University, Boston, MA, USA.
Joseph D PhillipsDivision of Thoracic Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Kayla A FayDivision of Thoracic Surgery, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Rachel WilliamsDivision of Cardiothoracic Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Joshua BoysDivision of Cardiovascular and Thoracic Surgery, Department of Surgery, University of California San Diego, San Diego, CA, USA.
Betul GundogduDepartment of Neurosciences, University of California San Diego, San Diego, CA, USA.
Matthew ElliotDepartment of Neurology, University of Virginia Health System, Charlottesville, VA, USA.
J Hunter MehaffeyDivision of Cardiothoracic Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, VA, USA.
Dustin M WaltersDivision of Thoracic Surgery, Department of Surgery, University of Connecticut, Farmington, CT, USA.ORCID https://orcid.org/0009-0005-1095-5825

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Trans-sternal thymectomy has been shown to be an effective treatment for select patients with non-thymomatous myasthenia gravis (MG). The purpose of this study was to evaluate whether similar neuromuscular benefits are achieved when utilizing minimally invasive surgical approaches to thymectomy, as compared to a trans-sternal approach, in patients with non-thymomatous MG. Methods: Pooled data for all patients undergoing thymectomy from 2012 to 2020 for non-thymomatous MG from four institutions were retrospectively reviewed. Patients were stratified by surgical approach, minimally invasive [robotic or video-assisted thoracoscopic (VATS) Results: A total of 54 patients were included with 54% (n=29) undergoing minimally invasive thymectomy (MIT) and 46% (n=25) undergoing a trans-sternal approach. There were no differences in baseline disease severity measured by proportion requiring intravenous immunoglobulin (IVIG), quantitative myasthenia scores, or daily prednisone dose. Similarly, there were no significant differences in major comorbidities. There was one conversion to a sternotomy for innominate vein bleeding. Perioperative complications were uncommon and largely similar between groups. Patients undergoing minimally invasive surgery had decreased length of hospital stay (2.5 Conclusions: Our study confirms the results of the landmark MGTX (Randomized Trial of Thymectomy in Myasthenia Gravis) trial in a real-world multicenter experience. Similar outcomes were achieved regardless of surgical approach. These data support thymectomy for MG either by a minimally invasive or trans-sternal approach. This is the first study to compare disease-specific, rather than perioperative, outcomes of thymectomy via sternotomy

Indexed as

myasthenia gravis (MG)robotic thoracic surgeryThymectomy

Identifiers

PMID41522102
PMCPMC12780441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.