ArticleQuantitative imaging in medicine and surgery2026
Association between atrial premature beat and left atrial function in hypertrophic cardiomyopathy on cardiovascular magnetic resonance myocardial tissue tracking: a reproducibility cohort study.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Applications of Left Atrial Strain in Cardiovascular Disease: A Comprehensive Review of Recent Evidence.Reviews in cardiovascular medicine · 2026Review
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5 authors.
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Abstract
Background: Hypertrophic cardiomyopathy (HCM) involves a substantial risk of atrial arrhythmia, with atrial premature beats (APBs)-a known precursor to atrial fibrillation (AF)-often signaling early atrial dysfunction. However, sensitive assessment of left atrial (LA) function in patients with HCM remains underoptimized. This study aimed to evaluate LA function in patients with HCM via cardiovascular magnetic resonance myocardial tissue tracking (CMR-TT) and to determine the associations between LA-related indices and APB. Methods: A total of 50 patients with obstructive HCM (HOCM), 54 patients with nonobstructive HCM (NOHCM), and 28 healthy controls were included in the study. CMR-TT was used to quantify LA functional parameters (including strain, strain rate, volume, and emptying fraction). Moreover, 24-hour Holter monitoring was applied to document the occurrence and calculate the frequency of APB. The primary analysis evaluated the association between LA strain and APB occurrence/frequency via logistic regression and correlation analyses, with adjustments made for potential confounders. The inter- and intraobserver reproducibility of LA strain measurements were assessed with intraclass correlation coefficients (ICCs). Results: LA function was decreased in patients with HCM as compared to controls. The patients with HOCM, as compared to those with NOHCM, had a significantly lower LA strain [total strain (εs): 17.7%±6.0%; passive strain (εe): 8.6%±4.3%; active strain (εa): 9.1%±3.7%] and strain rate [peak positive strain rate (SRs): 0.86±0.3 s Conclusions: CMR-TT is a promising approach for detecting atrial performance and physiology by quantitatively assessing LA deformation. Moreover, our findings demonstrate a clear association between lower LA εs and the occurrence of APB in patients with HCM. These results suggest that εs may serve as a potential indicator for reflecting atrial electrical instability in HCM and provide preliminary insights for further exploration of its role in clinical decision-making related to arrhythmia management in this patient population.
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