ArticleQuantitative imaging in medicine and surgery2026
Glymphatic system dysfunction in pediatric growth hormone deficiency evidenced by multiple MRI metrics.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Developmental changes in diffusion MRI metrics along the perivascular space in children during the first 5 years of life.Pediatric radiology · 2026Article
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10 authors.
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Abstract
Background: The clearance of brain metabolic waste occurs mainly through the glymphatic system. This study aimed to explore the change of glymphatic function in children with growth hormone deficiency (GHD) using non-invasive imaging methods. Methods: This prospective research recruited 40 cases of pediatric GHD and 40 age- and gender-matched typically developing (TD) children. Glymphatic circulation, which includes the production of cerebrospinal fluid (CSF), represented by choroid plexus volume (CPV), influx, evaluated by perivascular space (PVS) burden, and waste clearance, as indirectly assessed by diffusion tensor imaging-based analysis along the perivascular space (DTI-ALPS), was explored for all participants. Partial correlations were conducted between significant magnetic resonance imaging (MRI) metrics and clinical variables in GHD children. Results: Considering the production of CSF, decreased CPV was presented in pediatric GHD [0.77±0.15 Conclusions: Our findings suggest that glymphatic dysfunction may be a pathological mechanism in pediatric GHD. Furthermore, our study demonstrates that CPV, PVS volume, and DTI-ALPS index could serve as multiple auxiliary biomarkers for assessing the glymphatic function in pediatric GHD.
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