ArticleQuantitative imaging in medicine and surgery2026
Amide proton transfer-weighted imaging in predicting aggressiveness of hepatocellular carcinoma: comparison with diffusion-weighted imaging.
Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Magnetic resonance imaging R2* mapping for evaluating Ki-67 proliferation index and cytokeratin 19 expression in solitary iron-sparing hepatocellular carcinoma: a retrospective single-center study.Quantitative imaging in medicine and surgery · 2026Article
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Abstract
Background: Amide proton transfer-weighted (APTw) imaging provides molecular-level information for comprehensive tumor characterization, aiding in diagnosis, grading, and treatment response monitoring. The study aimed to investigate the potential of APT imaging in simultaneously predicting three key markers of hepatocellular carcinoma (HCC) aggressiveness-microvascular invasion (MVI), Ki-67 labeling index (LI) and histologic grade-and compare its performance to that of diffusion-weighted imaging (DWI). Methods: Fifty-six patients with histologically confirmed HCC underwent abdominal magnetic resonance imaging (MRI) including APTw and DWI. Tumor mean APTw and apparent diffusion coefficient (ADC) values were measured and correlated with Ki-67 LI. The differences of APTw and ADC values between MVI positive (MVI+) and negative (MVI-), high and low Ki-67 LI, and high- and low-grade HCC were analyzed. The diagnostic efficacy of APTw and ADC for predicting HCC aggressiveness was assessed using receiver operating characteristic (ROC) curve analysis. Results: APTw positively correlated with Ki-67 LI (ρ=0.49, P<0.001) and ADC negatively correlated with Ki-67 LI (ρ=-0.27, P=0.04). HCC with MVI+ had higher APTw values than MVI- (1.68%±1.02% Conclusions: APTw imaging could potentially provide additional value in assessing HCC aggressiveness, complementing the information obtained from DWI.
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