Observational studyRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia2026
[Risk factors associated with inadequacy of empirical treatment in patients with sepsis and bacteremia attended in an emergency department].
Observational study in Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- ASP-COMPLEX: redefining antimicrobial stewardship to improve outcomes in high-risk patients with severe infections.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionManagement of septic patients continues to be a major challenge in emergency departments, with hospital mortality exceeding 30%. Early and appropriate administration of antibiotic therapy is an essential pillar of initial treatment for sepsis, as delays or inadequacies significantly increase morbidity and mortality. However, the factors contributing to inadequate empirical treatment are still poorly understood. The objective of our study was to identify the risk factors associated with inadequate initial treatment in patients treated as code sepsis, as well as to evaluate the impact of the initial adequacy of empirical treatment on mortality. MATERIAL AND
methodsObservational, retrospective cohort study conducted in the emergency department of a tertiary hospital (2021-2024). Inclusion: adults over 18 years of age with activated sepsis codes and positive blood cultures. The adequacy of initial empirical treatment, associated risk factors, and their effect on 7- and 30-day mortality were analyzed.
results339 patients with sepsis were included; 56.9% were over 80 years of age. Factors associated with inadequate antibiotic treatment were
conclusionA significant proportion of patients with sepsis in emergency departments receive inadequate empirical therapy, which is associated with higher early mortality, especially in infections caused by S. aureus and multidrug-resistant bacteria.
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