Evidence map›Paper›PMID 41521864›Full record

SynthesisJournal of comparative effectiveness research2026

Effectiveness and safety of therapies for patients with opioid use disorder: a systematic review and network meta-analysis.

Madhusudan Kabra, Tushar Srivastava, Raju Gautam, Janharpreet Singh, Juha Oksanen, Tim MacDonald, Kenneth Lee, Brent Boyett, Bill Santoro, Anurag Gupta and 2 more

Abstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of comparative effectiveness research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madhusudan KabraIndivior Ltd, Slough, London, UK.ORCID 0000-0001-5089-9892
Tushar SrivastavaConnectHEOR Ltd, London, UK.
Raju GautamConnectHEOR Ltd, London, UK.
Janharpreet SinghDepartment of Population Health Sciences, University of Leicester, Leicester, UK.
Juha OksanenKotkan Korvaushoitoyksikkö (Kotka OST Clinic), Kotka, Finland.
Tim MacDonaldGriffith University, Brisbane, Queensland, Australia.
Kenneth LeeLondon RAAM Clinic, London, ON N6A 1J3, Canada.
Brent BoyettNorth Mississippi Medical Center of Tupelo, MS 38801, USA.
Bill SantoroSection of Addiction Medicine, Tower Health System, Reading, PA 19605, USA.
Anurag GuptaConnectHEOR, Delhi, India.
Anne De Jong-LairdEmployee of Indivior Ltd, Slough, UK when study was conducted.
Shijie RenConnectHEOR Ltd, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Analgesics, OpioidBuprenorphineOpiate Substitution TreatmentOpioid-Related DisordersDelayed-Action PreparationsHumansMethadoneQuality of LifeTreatment OutcomeAnalgesics, OpioidBuprenorphineDelayed-Action PreparationsMethadonenetwork meta-analysisobservational studyopioid use disorderrandomized controlled trialreal-world evidencesystematic literature review

Identifiers

PMID41521864
PMCPMC12884343

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.