Evidence map›Paper›PMID 41521838›Full record

ArticleJournal of global health2026

Association of sleep and glycaemic status with all-cause mortality: a prospective cohort study.

Andi Xu, Cao Zhi, Sicong Wang, Fei Cai, Zuhui Zhang, David Ta-Wei Chu, Wenyuan Li, Chi Pang Wen, Xifeng Wu

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Article in Journal of global health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Andi XuCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Cao ZhiCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Sicong WangCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Fei CaiCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Zuhui ZhangCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
David Ta-Wei ChuMJ Health Management Center, Taipei, Taiwan.
Wenyuan LiCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.
Chi Pang WenNational Institute for Data Science in Health and Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Xifeng WuCenter of Clinical Big Data and Analytics of The Second Affiliated Hospital, and School of Public Health, Zhejiang University School of Medicine, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Suboptimal sleep and diabetes are major contributors to mortality. However, whether sleep patterns differentially affect mortality across glycaemic statuses remains unclear. This study examined associations of sleep patterns (sleep duration and sleep disorders) with all-cause mortality among individuals with normoglycaemia, prediabetes, and diabetes. Methods: Data were obtained from the Taiwan MJ cohort, including 534 238 participants enrolled between 1996 and 2022. Sleep duration ('less than 6 hours', '6-8 hours', 'more than 8 hours') and sleep disorders (yes/no) were assessed via standardised questionnaires. Glycaemic status was classified as normoglycaemia, prediabetes, or diabetes. Mortality data were obtained from the Taiwan Death Registry. Cox proportional hazards regression models were employed to evaluate the association between sleep patterns and the risk of all-cause mortality. Results: The study included 363 863 participants with normoglycaemia, 144 602 with prediabetes, and 25 773 with diabetes. Over a median follow-up period of 19 years, 52 208 deaths were recorded. Compared with those who slept 6-8 hours, normoglycaemia individuals who slept less than 6 hours had a higher risk of all-cause mortality (hazard ratio (HR) = 1.05; 95% confidence interval (CI) = 1.02-1.08) and those who slept more than eight hours had a higher risk of all-cause mortality across all glycaemic groups: normoglycaemia (HR = 1.19; 95% CI = 1.15-1.24), prediabetes (HR = 1.24; 95% CI = 1.19-1.30), and diabetes (HR = 1.29; 95% CI = 1.22-1.36). Sleep disorders were also associated with increased mortality among individuals with prediabetes (HR = 1.04; 95% CI = 1.01-1.07) and diabetes (HR = 1.07; 95% CI = 1.02-1.11). Conclusions: Long sleep durations and sleep disorders were associated with increased mortality, especially among individuals with impaired glucose regulation while short sleep duration was discovered to associate with increased risk of mortality in people with normoglycaemia. These findings highlight the potential role of sleep assessment in risk stratification, although the observational nature of the study limits causal inference.

Indexed as

Blood GlucoseDiabetes MellitusMortalityPrediabetic StateSleepSleep Wake DisordersAdultAgedCause of DeathFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsSleep DurationBlood Glucose

Identifiers

PMID41521838
PMCPMC12793928

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.