ArticleJournal of clinical pharmacology2026
Performance of Estimated Kidney Function Equations for Predicting Aminoglycosides Clearance in Thai Population.
Article in Journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Disparities in the performance of various kidney function equations in predicting aminoglycoside clearance (CL) have been identified. However, data specific to the Thai population remains limited. This study aimed to evaluate the performance of kidney function equations in estimating aminoglycoside CL in Thai patients. Data were retrospectively collected from hospitalized Thai patients who received amikacin or gentamicin over a 10-year period. Population pharmacokinetic (PK) analysis was performed using a nonlinear mixed-effects modeling approach. The association between aminoglycoside CL and kidney function, estimated by various equations, was ranked based on the magnitude of change in the Akaike Information Criterion (AIC) relative to the base model. A total of 138 adult Thai patients treated with either gentamicin (66%) or amikacin (34%) were enrolled. The non-body surface area (BSA)-indexed estimated glomerular filtration rate (eGFR) equations showed a stronger association with aminoglycoside CL compared to the 1.73 m
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