Evidence map›Paper›PMID 41521805›Full record

ArticleCancer medicine2026

Risk of Type II Diabetes Mellitus Among B-Cell Non-Hodgkin's Lymphoma Survivors.

Ellenor Chi, Derek K Chang, Chun-Pin Esther Chang, Seungmin Kim, Jihye Park, John Snyder, Vikrant Deshmukh, Michael G Newman, Catherine J Lee, Mia Hashibe

Abstract read
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ellenor ChiSpencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0003-4894-2542
Derek K ChangSpencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.
Chun-Pin Esther ChangDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-0878-997X
Seungmin KimDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Jihye ParkDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-5082-4759
John SnyderIntermountain Healthcare, Salt Lake City, Utah, USA.
Vikrant DeshmukhUniversity of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Michael G NewmanUniversity of Utah Health Sciences Center, Salt Lake City, Utah, USA.
Catherine J LeeHuntsman Cancer Institute, Salt Lake City, Utah, USA.
Mia HashibeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.ORCID https://orcid.org/0000-0002-6903-2049

Funding

Population-based Cohort of Endometrial Cancer Survivors in UtahR21CA185811 · NCI · UNIVERSITY OF UTAH · PI HASHIBE, MIA · 2015 to 2016
$356k
Epidemiology of testicular cancer in the Utah populationR03CA159357 · NCI · UNIVERSITY OF UTAH · PI HASHIBE, MIA · 2011 to 2012
$150k
CDC HHS NU58DP007131Huntsman Cancer Institute, Cancer Control and Population Studies ProgramNCI NIH HHS HHSN261201800016INCI NIH HHS P30 CA2014NIH HHS R03 CA159357NIH HHS R21 CA185811Utah State Department of Health
6 · The paper itself

Abstract

purposeAdvancing therapies have increased B-cell Non-Hodgkin's Lymphoma (B-NHL) patient survival. However, data are limited on the risk of type II diabetes mellitus (type II DM) in adult survivors following treatment. This study examines the risk of type II DM among a Utah population of B-NHL survivors, compared to the general population.

methodsA cohort of 3529 adult survivors diagnosed with B-NHL in Utah between 1997 and 2013 in the Utah Cancer Registry and 13,339 individuals from the general population were identified using the Utah Population Database (UPDB). Multivariate Cox Proportional Hazard models were used to estimate adjusted hazard ratios (aHR) for developing type II DM, stratified for time post-diagnosis.

resultsCompared to the cancer-free population, B-NHL survivors had an overall increased risk of developing type II DM (HR: 1.49; 95% CI: 1.32, 1.69), largely within the first year (HR: 4.41; 95% CI: 3.52, 5.52) following diagnosis. Older B-NHL survivors were more likely to develop type II DM at any time compared to survivors < 40 years [40-65 years (HR: 2.66; 95% CI 1.48-4.79); ≥ 65 years (HR: 3.77; 95% CI 2.09-6.78)]. Obese (BMI > 30 kg/m

conclusionsAdult B-NHL cancer survivors were at an overall increased risk of developing type II DM compared to the general population, within the first year and overall, following a cancer diagnosis. This study provides evidence suggesting the importance of obesity prevention and improvement in care management oversight for B-NHL survivorship and DM outcomes.

Indexed as

Cancer SurvivorsDiabetes Mellitus, Type 2Lymphoma, B-CellAdultAgedFemaleHumansMaleMiddle AgedProportional Hazards ModelsRegistriesRisk FactorsUtahYoung AdultB‐cell non‐Hodgkin's lymphomacancer survivorsdiabetes mellituslate effectssurvivorship

Identifiers

PMID41521805
PMCPMC12793787

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.