Evidence map›Paper›PMID 41521781›Full record

ArticleMacromolecular rapid communications2026

Poly(sarcosine) Lipid Synthesis From CO

Florian T Kaps, Leon Quellmalz, Annika D S Richardson, Anna-Lena Ziegler, Sarah Moreau, Susanne K Wiedmer, Timo Repo, Robert Luxenhofer

Abstract read
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In one paragraph

Article in Macromolecular rapid communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Florian T KapsDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0009-0005-8518-0518
Leon QuellmalzDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0009-0000-8289-3014
Annika D S RichardsonDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0009-0009-6555-8869
Anna-Lena ZieglerDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0009-0003-6963-1628
Sarah MoreauDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.
Susanne K WiedmerDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-3097-6165
Timo RepoDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0002-3116-6199
Robert LuxenhoferDepartment of Chemistry, Faculty of Science, University of Helsinki, Helsinki, Finland.ORCID https://orcid.org/0000-0001-5567-7404

Funding

Academy of Finland 352397Research Council of Finland 352397
6 · The paper itself

Abstract

Polymer lipids (PLs) are an essential component for the stability of lipid nanoparticles (LNPs) for gene delivery. Poly(ethylene glycol) (PEG)-based lipids are the current gold standard. However, they are suspected to be responsible for rare adverse reactions to the LNP-based COVID-19 vaccines. Therefore, alternative PLs are being intensively investigated. A particularly promising alternative are poly(sarcosine) (PSar)-based lipids. However, one significant bottleneck of pSar-based biomaterials is the synthesis of the monomer sarcosine-N-carboxyanhydride (Sar-NCA). Current methods rely on highly toxic di- or triphosgene to obtain the monomer directly from the amino acid sarcosine. Herein, we present a phosgene-free, CO

Indexed as

AnhydridesCarbon DioxideLipidsPolymersSarcosineNanoparticlesPeptidesAnhydridesCarbon DioxideLipidsPeptidesPolymerspolysarcosineSarcosinecarbon dioxidegreen chemistrylipid nanoparticlespoly(sarcosine)sustainable

Identifiers

PMID41521781
PMCPMC13003720

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.