Evidence map›Paper›PMID 41521736›Full record

ArticleInternational journal of cancer2026

Outcomes from the English National Lynch Syndrome transformation project.

Kevin J Monahan, Paul Fleming, Neil A J Ryan, Laura Monje-Garcia, Ruth Armstrong, David N Church, Jackie Cook, Fiona Lalloo, Sally Lane, Frank D McDermott and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Outcomes of 'in-house' genetic testing within a specialist hereditary colorectal cancer registry.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Kevin J MonahanSt Mark's Hospital Centre for Familial Intestinal Cancer, London, UK.ORCID https://orcid.org/0000-0002-7918-4003
Paul FlemingSouth East Genomic Medicine Service Alliance, London, UK.
Neil A J RyanDepartment of Gynaecology Oncology, Royal Infirmary of Edinburgh, Edinburgh, UK.
Laura Monje-GarciaNorth West Genomic Medicine Service Alliance, Manchester, UK.
Ruth ArmstrongEast of England Genomic Medicine Service Alliance, Cambridge, UK.
David N ChurchWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Jackie CookNorth East and Yorkshire Genomic Medicine Service Alliance, Sheffield, UK.
Fiona LallooNorth West Genomic Medicine Service Alliance, Manchester, UK.
Sally LaneNorth East and Yorkshire Genomic Medicine Service Alliance, Sheffield, UK.
Frank D McDermottSouth West Genomic Medicine Service Alliance, Exeter, UK.
Tracie MilesSouth West Genomic Medicine Service Alliance, Exeter, UK.
Corinne MallinsonNational Disease Registration Service (NDRS), NHS England, Newcastle, UK.
Steven A HardyNational Disease Registration Service (NDRS), NHS England, Newcastle, UK.
Simone GelinasSouth East Genomic Medicine Service Alliance, London, UK.
Francesca FaravelliNorth Thames Genomic Medicine Service Alliance, London, UK.
Frances ElmslieSouth East Genomic Medicine Service Alliance, London, UK.
Adam C ShawSouth East Genomic Medicine Service Alliance, London, UK.

Funding

Cancer Research UK (CRUK) Advanced Clinician Scientist Fellowship C26642/A27963
6 · The paper itself

Abstract

The English National Health Service (NHS) Lynch Syndrome Transformation Project was established to deliver universal testing for Lynch syndrome (LS) of newly diagnosed colorectal (CRC) and endometrial cancer (EC). A central aim was to integrate 'mainstreamed' genetic testing into routine care by cancer multidisciplinary teams in England. In June 2021 national and regional LS project teams were established to support 'LS champions' within local cancer multidisciplinary teams (MDTs). A comprehensive retrospective genomic dataset and dashboard was compiled by the National Disease Registration Service (NDRS), complimented with prospective local MDT audit (2022-2023). A robust national registry of people diagnosed with LS was developed to ascertain individuals for targeted interventions, including for a new national LS Bowel Cancer Screening Programme (LS-BCSP). In total 276 LS champions were appointed and trained across 248 CRC and EC MDTs (>95% coverage nationally). Tumour Mismatch repair (MMR) tumour testing rates increased for CRC (43 >94%) and EC (19 >94%). MDT-led mainstreaming services were developed in 46% of all CRC and 41% EC teams in England. In subgroup data, the time to germline genetic testing was 21 days in 'mainstreamed' patients, versus 180 days referred to regional clinical genetics services. New diagnoses of LS have consistently increased each year from a total of 545 in 2020 to a total of 1394 in 2024 (an increase of 255% vs. a target of >50%). The NHS England LS Transformation project has driven equitable nationwide delivery of diagnosis testing for Lynch syndrome, with integration of 'mainstreamed' genetic testing into routine cancer care.

Indexed as

Colorectal Neoplasms, Hereditary NonpolyposisEndometrial NeoplasmsGenetic TestingColorectal NeoplasmsDNA Mismatch RepairEarly Detection of CancerEnglandFemaleHumansMaleMiddle AgedRegistriesRetrospective StudiesColorectal CancerEndometrial CancerGenetic testingLynch syndrome

Identifiers

PMID41521736
PMCPMC12963710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.