Evidence map›Paper›PMID 41521555›Full record

ArticleJournal of medicinal chemistry2026

Discovery of Fragment-Based Inhibitors of SARS-CoV-2 PL

Qiangqiang Wei, Ashley J Taylor, Mahesh Angadrao Barmade, Kevin B Teuscher, Somanath Chowdhury, Chideraa Apakama, Jordan Anderson-Daniels, Zhu Yongqing, David C Schultz, Tyson A Rietz and 10 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Qiangqiang WeiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Ashley J TaylorDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-0568-7652
Mahesh Angadrao BarmadeDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0002-8685-7333
Kevin B TeuscherDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0009-0008-1039-015X
Somanath ChowdhuryDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Chideraa ApakamaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Jordan Anderson-DanielsDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Zhu YongqingDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
David C SchultzDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Tyson A RietzDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0003-4670-5279
Taylor M SouthDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Mackenzie M CrowDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Bin ZhaoDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Kangsa AmporndanaiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0001-8527-9394
John L SensintaffarDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Jason PhanDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Sara CherryDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Mark DenisonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States.
Taekyu LeeDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.
Stephen W FesikDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States.ORCID 0000-0001-5957-6192

Funding

Research Project 1: Coronavirus antiviral lead development and combination testingU19AI171292 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARIC, RALPH S, WILLSON, TIMOTHY M · 2022 to 2022
$65.5M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Integrated ImageXpress Micro Confocal High Content Screening SystemS10OD028719 · OD · VANDERBILT UNIVERSITY · PI BAUER, JOSHUA A. · 2021 to 2021
$799k
Automated Compound Storage and Retrieval SystemS10OD028715 · OD · VANDERBILT UNIVERSITY · PI BAUER, JOSHUA A. · 2022 to 2022
$741k
NIAID NIH HHS U19 AI171292NIGMS NIH HHS P30 GM124169NIH HHS S10 OD028715NIH HHS S10 OD028719
6 · The paper itself

Abstract

SARS-CoV-2 papain-like protease (PL

Indexed as

Antiviral AgentsCoronavirus Papain-Like ProteasesSARS-CoV-2AnimalsCOVID-19 Drug TreatmentCrystallography, X-RayDrug DiscoveryHumansModels, MolecularStructure-Activity RelationshipAntiviral AgentsCoronavirus Papain-Like Proteasespapain-like protease, SARS-CoV-2

Identifiers

PMID41521555
PMCPMC12833870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.