ArticleACS applied materials & interfaces2026
Glycosaminoglycan-Inspired Polymer Brushes Promote Human Mesenchymal Stem Cell Proliferation While Retaining Trilineage Differentiation Potential.
Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human mesenchymal stem/signaling cells (hMSCs) are promising therapeutics for cancer, autoimmune disorders, and musculoskeletal conditions. Given that the hMSC proliferation capacity and therapeutic potency diminish rapidly over extended passaging, expanding hMSCs into populations sufficient for clinical use remains an outstanding challenge. In this work, we synthesized cell culture substrates that mimicked key structural features of glycosaminoglycans or GAGs (e.g., brush architecture and sulfonation). hMSCs proliferated up to 40% more rapidly on GAG-inspired sulfonated polymer brushes than on currently used tissue culture polystyrene substrates (TCPs). In addition to rapid proliferation, hMSCs expanded on these sulfonated polymer brushes still retained their capacity to differentiate into adipogenic, chondrogenic, and osteogenic lineages. We synthesized 8 polymer brushes with varying sulfonation, hydroxylation, and hydrophobicity. Five of these synthesized polymer brushes outperformed TCPs in hMSC proliferation assays conducted in chemically defined serum-free cell culture media. In comparing the fold change of hMSC numbers over 7 days in culture, brushes with higher sulfonation degrees (88%) and moderate hydrophilicity (37°-48° water contact angles) performed 30-40% better than TCPs. We then selected hMSCs expanded on the polymer brushes with the most consistent proliferation trends (S75H25) for further biological characterization. Genes associated with proliferation (
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