Evidence map›Paper›PMID 41521357›Full record

ArticleAnnals of hematology2026

Hypomethylating agents alone or in combination with venetoclax in very elderly acute myeloid leukemia patients: less treatment, better care?

Francesco Tarantini, Corinne Contento, Ernesto Vigna, Vera Carluccio, Giuseppina Greco, Crescenza Pasciolla, Lucia Ciuffreda, Giovanni Rossi, Marina Aurora Urbano, Alessandro D'Ambrosio and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Francesco TarantiniDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Corinne ContentoHematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, 73100, Lecce, Italy.
Ernesto VignaDepartment of Onco-Hematology, Hematology Unit, Cosenza, Italy.
Vera CarluccioHematology and Transplant Unit, Dimiccoli Hospital, 76121, Barletta, BT, Italy.
Giuseppina GrecoHematology and Transplant Unit, Cardinal Panico Hospital, 73039, Tricase, Italy.
Crescenza PasciollaU.O. Di Ematologia, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
Lucia CiuffredaHematology and Transplant Unit, Policlinico Foggia Ospedaliero-Universitario, Foggia, Italy.
Giovanni RossiHematology, Ospedale Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
Marina Aurora UrbanoHematology Unit, A. Perrino Hospital, 72100, Brindisi, Italy.
Alessandro D'AmbrosioAORN S. Anna E S. Sebastiano, Caserta, Italy.
Lara AprileHematology Unit, Department of Hematology-Oncology, Moscati Hospital, 74010, Taranto, Italy.
Vito Pier GagliardiDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Mario DeliaDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Immacolata AttolicoDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Paola CarluccioDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Vincenzo FedericoHematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, 73100, Lecce, Italy.
Antonella BruzzeseDepartment of Onco-Hematology, Hematology Unit, Cosenza, Italy.
Nicola Di RenzoHematology and Stem Cell Transplant Unit, "Vito Fazzi" Hospital, 73100, Lecce, Italy.
Massimo GentileDepartment of Onco-Hematology, Hematology Unit, Cosenza, Italy.
Giuseppe TarantiniHematology and Transplant Unit, Dimiccoli Hospital, 76121, Barletta, BT, Italy.
Anna MeleHematology and Transplant Unit, Cardinal Panico Hospital, 73039, Tricase, Italy.
Attilio GuariniU.O. Di Ematologia, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy.
Lorella Maria Antonia MelilloHematology and Transplant Unit, Policlinico Foggia Ospedaliero-Universitario, Foggia, Italy.
Angelo Michele CarellaHematology, Ospedale Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Foggia, Italy.
Domenico PastoreHematology Unit, A. Perrino Hospital, 72100, Brindisi, Italy.
Ferdinando FrigeriAORN S. Anna E S. Sebastiano, Caserta, Italy.
Alessandro MaggiHematology Unit, Department of Hematology-Oncology, Moscati Hospital, 74010, Taranto, Italy.
Cosimo CumboDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Giorgina SpecchiaSchool of Medicine, University of Bari "Aldo Moro", 70124, Bari, Italy.
Pellegrino MustoDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy.
Francesco AlbanoDepartment of Precision and Regenerative Medicine and Ionian Area - DiMePRe-J - Azienda Ospedaliero Universitaria Consorziale Policlinico - Hematology and Stem Cell Transplantation Unit, University of Bari "Aldo Moro", P.zza G. Cesare, 11, 70124, Bari, Italy. francesco.albano@uniba.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypomethylating agents (HMA) alone or in combination with venetoclax (VEN) are a mainstay for disease control in elderly acute myeloid leukemia (AML). We evaluated the non-inferiority of HMA monotherapy compared to HMA/VEN combination in 227 AML patients aged ≥ 75 years receiving HMA or HMA/VEN combination. No difference in overall survival (OS) was observed between the two groups, with HMA monotherapy demonstrating statistical non-inferiority. HMA-treated patients with favorable performance status had longer OS. The HMA/VEN group experienced higher mortality and worse QoL. HMA monotherapy offers comparable survival outcomes to HMA/VEN with reduced toxicity in elderly AML patients.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsBridged Bicyclo Compounds, HeterocyclicDNA MethylationLeukemia, Myeloid, AcuteSulfonamidesAgedAged, 80 and overDecitabineFemaleHumansMaleBridged Bicyclo Compounds, HeterocyclicDecitabineSulfonamidesvenetoclaxElderly acute myeloid leukemiaHypomethylating agentsQoLVenetoclax

Identifiers

PMID41521357
PMCPMC12791063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.