Evidence map›Paper›PMID 41521275›Full record

ArticleCancer medicine2026

Impact of In-Office Dispensing Adoption by Urology Practices on Oral Specialty Drug Use in Advanced Prostate Cancer.

Kassem S Faraj, Mary Oerline, Samuel R Kaufman, Christopher Dall, Arnav Srivastava, Xiu Liu, Megan E V Caram, Vahakn B Shahinian, Brent K Hollenbeck

Abstract read
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kassem S FarajDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-2130-0446
Mary OerlineDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Samuel R KaufmanDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Christopher DallDepartment of Urology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Arnav SrivastavaDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-9772-1415
Xiu LiuDepartment of Urology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Megan E V CaramVA Health Services Research & Development, Center for Clinical Management Research, VA Ann Arbor Healthcare System, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0003-1597-5428
Vahakn B ShahinianDivision of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Brent K HollenbeckDow Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Advanced Training in Urologic OncologyT32CA180984 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu, VAHAKN B SHAHINIAN · 2014 to 2026
$3.4M
Physician dispensing of oral specialty drugs for advanced prostate cancer and its implications for patientsR01CA275993 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLLENBECK, BRENT K., SHAHINIAN, VAHAKN B · 2023 to 2025
$2.5M
Urology practice consolidation and care for men with prostate cancerR01CA279746 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENT K. HOLLENBECK, Andrew M Ryan · 2024 to 2026
$1.8M
NCI NIH HHS CA180984NCI NIH HHS CA275993NCI NIH HHS CA279746NCI NIH HHS R01 CA275993NCI NIH HHS R01 CA279746NCI NIH HHS T32 CA180984
6 · The paper itself

Abstract

introductionA paradigm shift in advanced prostate cancer toward the use of oral specialty drugs has been accompanied by increased involvement of urologists. In fact, some urology groups can deliver these medications in the office, providing them directly to their patients.

methodsA retrospective cohort study was performed using a 20% national sample of men with advanced prostate cancer enrolled in Traditional Medicare and managed by independent urology groups between 2011 and 2019. Urology groups with and without in-office dispensing were identified. Multivariable logistic regression was used to assess relationships between urology group characteristics and in-office dispensing. A difference-in-differences design was used to measure the effect of in-office dispensing on the use of oral specialty drugs within urology group markets compared to markets without dispensing.

resultsUrology group characteristics associated with adoption of in-office dispensing included large practice size (OR 2.9, 95% CI 1.2-6.5), increasing volume of men with advanced prostate cancer (OR 1.1 per 10-patient increase, 95% CI 1.0-1.2), decreasing social vulnerability of the group's patient population (OR 0.81 per 0.1 unit increase, 95% CI 0.69-0.95), lower competition (OR 1.02 per 100 unit increase in the Herfindahl-Hirschman Index, 95% CI 1.0-1.1), and radiation vault ownership (OR 3.1, 95% CI 1.1-8.4). Compared with markets of urology groups that did not adopt in-office dispensing, adopting markets experienced a significant increase in oral specialty drug prescriptions (adjusted difference-in-differences estimate, 46 prescriptions per 1000 men, p < 0.001).

conclusionsAdoption of in-office dispensing by independent urology groups increased oral specialty drug prescriptions for advanced prostate cancer within a group's market.

Indexed as

Practice Patterns, Physicians'Prostatic NeoplasmsUrologyAdministration, OralAgedDrug DispensariesHumansMaleMedicareRetrospective StudiesUnited Statesadvanced prostate cancerfinancial incentivesprostate cancer

Identifiers

PMID41521275
PMCPMC12791029

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.