Evidence map›Paper›PMID 41521225›Full record

ArticleCellular and molecular life sciences : CMLS2026

HOXC6 overexpression stimulates cell migration and correlates with poor prognosis in head and neck squamous cell carcinoma.

Subhendu Roy Choudhury, Ishita Gupta, Ian Mills, Vera Mukhina, Andrey Loginov, Erin Allor, Alexa Anderson, Ashley Cellini, Carol Robles, Donita Dyalram and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Subhendu Roy Choudhury *Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Ishita Gupta *Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Ian MillsInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Vera MukhinaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Andrey LoginovInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Erin AllorInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Alexa AndersonInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Ashley CelliniUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Carol RoblesUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Donita DyalramDepartment of Otorhinolaryngology-Head and Neck Surgery, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
Joshua LubekDepartment of Otorhinolaryngology-Head and Neck Surgery, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
Jeffrey WolfDepartment of Otorhinolaryngology-Head and Neck Surgery, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
Rodney TaylorDepartment of Otorhinolaryngology-Head and Neck Surgery, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
Kyle HattenDepartment of Otorhinolaryngology-Head and Neck Surgery, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland Medical Center, Baltimore, MD, USA.
Nadezhda VorobyevaInstitute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.
Daria A GaykalovaInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. dgaykalova@som.umaryland.edu.ORCID http://orcid.org/0000-0001-5037-0147

Funding

Study of Biological and Radiographic Biomarkers and Association with Ancestry and Survival Disparities in Oral Cavity Squamous Cell Carcinoma Using AI ApproachesR01DE033426 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI Daria A Gaykalova, Ranee Mehra · 2024 to 2026
$2.0M
American Cancer Society RSG-21-020-01-MPCFoundation for the National Institutes of Health R01DE033426NCI NIH HHS 30006561NIDCR NIH HHS R01 DE033426
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and accounts for 2% of cancer-related deaths. Although the oncogenic role of HOXC6 in solid tumors is known, its functional relevance in HNSCC remains elusive. Using The Cancer Genome Atlas (TCGA, with 520 HNSCC samples) data and in vitro models, we investigated the functional role of HOXC6 in HNSCC. TCGA analysis revealed that HOXC6 overexpression in HNSCC tissues correlated with malignant progression and poor survival outcomes. In vitro studies confirmed HOXC6 overexpression in HNSCC cell lines, and knockdown of HOXC6 significantly reduced both cell proliferation and migration, highlighting the oncogenic role of HOXC6. Additionally, pathway analysis of RNA-seq data linked HOXC6 expression with immune evasion and dysregulation of cell cycle genes, particularly the E2F and G2M checkpoints. Furthermore, H3K27ac ChIP-seq data showed that histone acetylation at the HOXC6 promoter drives HOXC6 overexpression. This study identified HOXC6 as a key oncogenic driver in HNSCC and as a candidate biomarker for HNSCC. Targeting HOXC6 could pave the way for improved biomarker-driven approaches in HNSCC treatment to reduce recurrence and improve patient survival rates.

Indexed as

Cell MovementGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHomeodomain ProteinsSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorCell Line, TumorCell ProliferationHumansPrognosisBiomarkers, TumorHomeodomain ProteinsHOXC6 protein, humanBiomarkerHNSCCHOXC6Oncogene

Identifiers

PMID41521225
PMCPMC12858702

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.