Evidence map›Paper›PMID 41521185›Full record

ArticleScientific reports2026

Pulmonary vein isolation with a pulsed field system leads to lower levels of miR-23a-3p in the left atrial blood compared to a cryoballoon.

Andreas Zietzer, Vincent Knappe, Frederick Braun, Philip Düsing, Sophia Grunewald, Ansgar Ackerschott, Laurine Reese, Marko Bulic, Maximilian Funken, Christopher Gestrich and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andreas ZietzerHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany. andreas.zietzer@ukbonn.de.
Vincent KnappeHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Frederick BraunHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Philip DüsingHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Sophia GrunewaldHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Ansgar AckerschottHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Laurine ReeseHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Marko BulicHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Maximilian FunkenHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Christopher GestrichHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Georg NickenigHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.
Thomas BeiertHeart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, University of Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrial fibrillation (AF) is the most common arrhythmic disease in humans, with its incidence rising over the past decade. Novel treatment options for AF include pulsed field ablation (PFA) of the pulmonary veins through electroporation. While this technique is thought to be less damaging to surrounding tissue, the acute effects of PFA on the atrium are only incompletely understood. An analysis of circulating microRNAs (miRs) potentially released by local tissue damage due to PFA, in comparison to other standard ablation procedures, has not yet been performed. Small RNA sequencing analysis was performed on left atrial blood samples from four patients after PFA and five patients after cryoballoon ablation (CBA). In this pilot analysis, 154 miRs were stably detected across all samples. The expression of the two miRs with the lowest p-values was validated in 20 PFA cases versus 25 CBA cases via real-time PCR. We found hsa-miR-23a-3p to be significantly less abundant in plasma in the left atrium after PFA compared to CBA. The circulating miR signature in the left atrium is differentially affected by PFA compared to CBA. This finding potentially influences the use of miRs as biomarkers for prediction of outcomes after ablation.

Indexed as

Atrial FibrillationCatheter AblationCryosurgeryHeart AtriaMicroRNAsPulmonary VeinsAgedFemaleHumansMaleMiddle AgedMicroRNAsAtrial fibrillationCryoballoon ablationMicroRNANext generation sequencingPulsed field ablation

Identifiers

PMID41521185
PMCPMC12796457

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.